Metabolic inflammation is associated with increased expression of a saturated free fatty acid, proinflammatory cytokines, chemokines, and adipose oxidative stress. Macrophage inflammatory protein (MIP) -1α recruit inflammatory cells such as monocytes, macrophages, and neutrophils in adipose tissue; However, the mechanism of promoting the expression of MIP-1α remains unclear.
We hypothesized that the co-induced by palmitate and tumor necrosis factor (TNF) -α in monocytic cells / macrophages can be further enhanced by the presence of reactive oxygen species (ROS) -mediated oxidative stress MIP-1α. To investigate this, THP-1 cells monocytic and human macrophages primary co-stimulated by palmitate and TNF-α and mRNA and protein levels of MIP-1α was measured by using transcription quantitative reverse, polymerase chain reaction (qRT-PCR) and commercial tests enzyme -linked immunosorbent assay (ELISA), respectively.
Cognate receptors of palmitic, pulses like receptor (TLR) -4, was blunted by genetic ablation, neutralization, and chemical inhibition. The involvement of TLR4-downstream pathway, interferon regulatory factor (IRF) -3 or myeloid differentiation (MYD) -88 factors, determined by using IRF3-siRNA or MyD88-deficient cells. induced oxidative stress in cells by hydrogen peroxide (H2O2) and ROS induction treatment was measured with dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay. Data show that MIP-1α gene expression / protein upregulated in cells co-stimulated by palmitate / TNF-α compared with those stimulated with either palmitic or TNF-α (P <0.05).
Furthermore, TLR4-IRF3 the pathway involved in cooperative induction of MIP-1α in THP-1 cells, and this kooperatititas between palmitate and TNF-α is a clathrin-dependent and is also required signal through the c-Jun and nuclear factor kappa-light- to medium-chain enhancer activated B cells (NF-kB). In particular, the ROS itself induced MIP-1α and could further promote the secretion of MIP-1α together with palmitate and TNF-α. In conclusion, palmitic and TNF-α co-induced MIP-1α in human monocytic cells via TLR4-IRF3 and signaling pathways involving c-Jun / NF-kB. Importantly, oxidative stress leads to ROS-driven amplification MIP-1α, which may have significance for inflammatory metabolism.
MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress
Progress in Regulating Cancer tumorigenicity and metastasis through TrkB signaling
Clinical Pathology various human malignancies supported by tropomyosin receptor kinase (Trk) B specific receptor TrkB which is derived neurotrophic factor from binding brain (BDNF) and TrkB .TrkB fusion protein has been observed for over-expressed in many cancer patients. In addition, they observed in several cell types. A multiple signaling pathways may be affected by abnormal activation pathway of BDNF / TrkB. These signaling pathways in-clude PI3K / Akt, transactivation of EGFR, phospholipase C-gamma (PLCγ) pathway, Ras-Raf-MEK-ERK pathway, Jak / STAT pathway, and nuclear factor kappa-light-chain-enhancer of B cells activated (NF-kB) pathway.
Rabbit anti-Human IgM (µ chain), F(ab)'2 Fragment
AS16-3370
Agrisera AB
1 mg
EUR 250
Donkey anti-Mouse IgG (H&L), F(ab)'2 Fragment
AS16-3437
Agrisera AB
1,0 mg
EUR 224
Donkey anti-Rabbit IgG (H&L), F(ab)'2 Fragment
AS16-3521
Agrisera AB
1,0 mg
EUR 206
Goat anti-Human IgG Fc, F(ab)'2 fragment, FITC conjugated
AS10-1236
Agrisera AB
0,5 mg
EUR 233
Goat anti-Human IgG Fc, Biotin conjugated, F(ab)'2 fragment
AS10-806
Agrisera AB
0,5 mg
EUR 206
Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, Unconjugated
AS10-846
Agrisera AB
1 mg
EUR 206
Goat anti-Human IgG Fc, F(ab)'2 Fragment, DyLight® 488 conjugated, min, cross-reactivity to human IgA, IgM or IgG F(ab)'2 fragment
AS16-3353
Agrisera AB
0,5 mg
EUR 196
Donkey anti-Mouse IgG (H&L), F(ab)'2 Fragment, FITC conjugated
AS16-3450
Agrisera AB
0,5 mg
EUR 206
Donkey anti-Mouse IgG (H&L), F(ab)'2 Fragment, HRP conjugated
AS16-3454
Agrisera AB
0,5 mg
EUR 233
Donkey anti-Mouse IgG (H&L), F(ab)'2 Fragment, TRITC conjugated
AS16-3467
Agrisera AB
0,5 mg
EUR 206
Goat anti-Human IgM (µ chain), F(ab)'2 fragment, HRP conjugated
AS10-1009
Agrisera AB
0,5 mg
EUR 246
Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, FITC conjugated
AS10-1011
Agrisera AB
0,5 mg
EUR 185
Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, TRITC conjugated
AS10-1018
Agrisera AB
0,5 mg
EUR 185
Goat anti-Human IgG + IgA + IgM, F(ab)'2 fragment, HRP conjugated
AS10-1039
Agrisera AB
0,5 mg
EUR 246
Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, HRP conjugated
AS10-1045
Agrisera AB
0,5 mg
EUR 246
Goat anti-Human IgA (alpha chain), F(ab)'2 fragment, FITC conjugated
AS10-1076
Agrisera AB
0,5 mg
EUR 239
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin conjugated
AS10-1081
Agrisera AB
0,5 mg
EUR 233
Goat anti-Human IgA (alpha chain), F(ab)'2 fragment, TRITC conjugated
AS10-1097
Agrisera AB
0,5 mg
EUR 233
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, ALP conjugated
AS10-1139
Agrisera AB
0,5 mg
EUR 233
Goat anti-Human IgM (µ chain), F(ab)'2 fragment, Biotin conjugated
AS10-1200
Agrisera AB
0,5 mg
EUR 246
Goat anti-Human IgA + IgG + IgM, F(ab)'2 fragment, ALP conjugated
AS10-1222
Agrisera AB
0,5 mg
EUR 233
Goat anti-Human IgM (µ chain), F(ab)'2 fragment, ALP conjugated
AS10-1237
Agrisera AB
0,5 mg
EUR 246
Goat anti-Human IgA + IgG + IgM, F(ab)'2 fragment, Biotin conjugated
AS10-1253
Agrisera AB
0,5 mg
EUR 233
Goat anti-Human IgA + IgG + IgM, F(ab)'2 fragment, FITC conjugated
AS10-1275
Agrisera AB
0,5 mg
EUR 233
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugated
AS10-1289
Agrisera AB
0,5 mg
EUR 175
Goat anti-Human IgG (H&L), F(ab)'2 fragment, FITC conjugated
AS10-1295
Agrisera AB
0,5 mg
EUR 185
Goat anti-Human IgA + IgG + IgM, F(ab)'2 fragment, TRITC conjugated
AS10-1306
Agrisera AB
0,5 mg
EUR 233
Goat anti-Human IgA heavy (alpha chain), F(ab)'2 fragment, Unconjugated
AS10-743
Agrisera AB
1 mg
EUR 206
Goat anti-Human IgG (H&L), F(ab)'2 fragment, ALP conjugated
AS10-774
Agrisera AB
0,5 mg
EUR 206
Goat anti-Human IgG (H&L), F(ab)'2 fragment, Biotin conjugated
AS10-775
Agrisera AB
0,5 mg
EUR 206
Goat anti-Human IgG (H&L), F(ab)'2 fragment, HRP conjugated
AS10-779
Agrisera AB
0,5 mg
EUR 206
Goat anti-Human IgG Fc, F(ab)'2 fragment, Affinity purified, Unconjugated
AS10-805
Agrisera AB
1 mg
EUR 233
Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, ALP conjugated
AS10-848
Agrisera AB
0,5 mg
EUR 233
Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, Biotin conjugated
AS10-849
Agrisera AB
0,5 mg
EUR 206
Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, HRP conjugated
AS10-852
Agrisera AB
0,5 mg
EUR 206
Goat anti-Human IgG (H&L), F(ab)'2 fragment, TRITC conjugated
AS10-946
Agrisera AB
0,5 mg
EUR 185
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, FITC conjugated
AS10-967
Agrisera AB
0,5 mg
EUR 175
Goat anti-Human IgM (µ chain), F(ab)'2 fragment, FITC conjugated
AS10-991
Agrisera AB
0,5 mg
EUR 246
Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, Biotin conjugated
AS10-997
Agrisera AB
0,5 mg
EUR 246
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated
AS10-998
Agrisera AB
0,5 mg
EUR 185
Goat anti-Human IgM (µ chain), F(ab)'2 fragment, Affinity purified, Unconjugated
AS10-1029
Agrisera AB
1 mg
EUR 246
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated
AS10-1163
Agrisera AB
1 mg
EUR 175
Goat anti-Human IgA + IgG + IgM, F(ab)'2 fragment, Affinity purified, Unconjugated
AS10-1184
Agrisera AB
1 mg
EUR 175
TSH (beta) | thyroid stimulating hormone (Affinity purified, F(ab)2' fragment, goat antibody)
AS10-1325
Agrisera AB
0,5 mg
EUR 532
Goat anti-Human IgA heavy (alpha chain), F(ab)'2 fragment, Biotin conjugated
AS10-745
Agrisera AB
0,5 mg
EUR 233
Goat anti-Human IgA heavy (alpha chain), F(ab)'2 fragment, HRP conjugated
AS10-746
Agrisera AB
0,5 mg
EUR 206
Goat anti-Human IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated
AS10-773
Agrisera AB
1 mg
EUR 206
Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated
AS10-960
Agrisera AB
1 mg
EUR 233
EGFR (Ab-869) Antibody
21222
SAB
100ul
EUR 319
EGFR (Ab-869) Antibody
21222-100ul
SAB
100ul
EUR 302.4
EGFR (Ab-869) Antibody
21222-50ul
SAB
50ul
EUR 224.4
EGFR (Ab-869) Antibody
8B7065
AAT Bioquest
50ug
EUR 368
Description: EGFR (Ab-869) Antibody
EGFR (Ab-869) Antibody
MBS7131969-01mL
MyBiosource
0.1mL
EUR 270
EGFR (Ab-869) Antibody
MBS7131969-5x01mL
MyBiosource
5x0.1mL
EUR 1200
EGFR (Ab-869) Antibody
E11-7065B
EnoGene
100μg/100μl
EUR 225
Description: Available in various conjugation types.
EGFR (Ab-869) Antibody
E021222-1
EnoGene
50μg/50μl
EUR 100
Description: Available in various conjugation types.
EGFR (Ab-869) Antibody
E021222-2
EnoGene
100μg/100μl
EUR 170
Description: Available in various conjugation types.
anti-EGFR (Ab-869)
LF-PA20123
Abfrontier
100 ul
EUR 400.8
Description: Rabbit polyclonal to EGFR
EGFR (Ab-869) Antibody
CSB-PA877124-
Cusabio
each
EUR 402
Description: A polyclonal antibody against EGFR (Ab-869). Recognizes EGFR (Ab-869) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:200
EGFR (Ab-869) Antibody
CSB-PA877124-100ul
Cusabio
100ul
EUR 379.2
Description: A polyclonal antibody against EGFR (Ab-869). Recognizes EGFR (Ab-869) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:200
EGFR (Ab-869) Antibody
MBS856842-005mg
MyBiosource
0.05mg
EUR 190
EGFR (Ab-869) Antibody
MBS856842-01mg
MyBiosource
0.1mg
EUR 255
EGFR (Ab-869) Antibody
MBS856842-01mLAF405M
MyBiosource
0.1mL(AF405M)
EUR 465
EGFR (Ab-869) Antibody
MBS856842-01mLAF546
MyBiosource
0.1mL(AF546)
EUR 465
EGFR (Ab-869) Antibody
MBS856842-01mLAF750
MyBiosource
0.1mL(AF750)
EUR 465
EGFR (Ab-869) Antibody
MBS858436-01mg
MyBiosource
0.1mg
EUR 305
EGFR (Ab-869) Antibody
MBS858436-01mLAF405L
MyBiosource
0.1mL(AF405L)
EUR 465
EGFR (Ab-869) Antibody
MBS858436-01mLAF405S
MyBiosource
0.1mL(AF405S)
EUR 465
EGFR (Ab-869) Antibody
MBS858436-01mLAF610
MyBiosource
0.1mL(AF610)
EUR 465
EGFR (Ab-869) Antibody
MBS858436-01mLAF635
MyBiosource
0.1mL(AF635)
EUR 465
EGFR (Ab-869) Antibody
MBS9409871-005mL
MyBiosource
0.05mL
EUR 245
EGFR (Ab-869) Antibody
MBS9409871-01mL
MyBiosource
0.1mL
EUR 305
EGFR (Ab-869) Antibody
MBS9409871-5x01mL
MyBiosource
5x0.1mL
EUR 1230
Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 633 conjugated
AS12-2182
Agrisera AB
0,5 mg
EUR 206
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 633 conjugated
AS12-2189
Agrisera AB
0,5 mg
EUR 206
Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, DyLight® 800 conjugated
AS12-2381
Agrisera AB
0,5 mg
EUR 233
Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 800 conjugated
AS12-2428
Agrisera AB
0,5 mg
EUR 246
Donkey anti-Rabbit IgG (H&L), F(ab)'2 Fragment, DyLight® 488 conjugated
AS16-3526
Agrisera AB
0,5 mg
EUR 233
Goat anti-Rabbit IgG (H&L), F(ab)'2 Fragment, DyLight® 488 conjugated
AS16-3527
Agrisera AB
0,5 mg
EUR 202
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 488 conjugated
AS10-1220
Agrisera AB
0,5 mg
EUR 206
Goat anti-Rat IgG (H&L), F(ab)'2 fragment, HRP conjugated, min,reactivity to human, mouse IgG
AS10-1145
Agrisera AB
0,5 mg
EUR 246
Goat anti-Human IgG Fc, F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity bovine/mouse/rabbit serum
AS10-814
Agrisera AB
0,5 mg
EUR 246
Goat anti-Human IgG Fc, F(ab)'2 fragment, HRP conjugated, min, cross-reactivity bovine/mouse/rabbit serum
AS10-817
Agrisera AB
0,5 mg
EUR 233
Goat anti-Human IgM (µ chain), F(ab)'2 Fragment, min, cross-reactivity to IgG from human or mouse
AS16-3371
Agrisera AB
1,0 mg
EUR 238
Goat anti-Human IgG Fc, F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine,mouse,rabbit serum
AS10-1001
Agrisera AB
0,5 mg
EUR 246
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to human IgG/serum
AS10-1002
Agrisera AB
0,5 mg
EUR 233
Goat anti-Rat IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to human, mouse IgG
AS10-1023
Agrisera AB
0,5 mg
EUR 246
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to human IgG/serum
As10-1071
Agrisera AB
0,5 mg
EUR 233
Goat anti-Rat IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to human, mouse IgG
AS10-1088
Agrisera AB
0,5 mg
EUR 246
Goat anti-Human IgG Fc, F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovine,mouse,rabbit serum
AS10-1099
Agrisera AB
0,5 mg
EUR 246
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to human IgG/serum
AS10-1189
Agrisera AB
0,5 mg
EUR 233
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, ALP conjugated, min, cross-reactivity to human IgG/serum
AS10-1193
Agrisera AB
0,5 mg
EUR 246
Goat anti-Rat IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to human, mouse IgG
AS10-1234
Agrisera AB
0,5 mg
EUR 246
Goat anti-Human IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity bovine/mouse/rabbit serum
AS10-782
Agrisera AB
0,5 mg
EUR 233
Goat anti-Human IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity bovine/mouse/rabbit serum
AS10-785
Agrisera AB
0,5 mg
EUR 233
Goat anti-Human IgG Fc, F(ab)'2 fragment, ALP conjugated, min, cross-reactivity to bovine/mouse/rabbit serum
AS10-813
Agrisera AB
0,5 mg
EUR 246
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to human IgG/serum
AS10-981
Agrisera AB
0,5 mg
EUR 233
Goat anti-Human IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovine,mouse,rabbit serum
AS10-1015
Agrisera AB
0,5 mg
EUR 233
Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to human, mouse,Rat IgG
AS10-1058
Agrisera AB
0,5 mg
EUR 246
Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to human, mouse,Rat IgG
AS10-1065
Agrisera AB
0,5 mg
EUR 246
Goat anti-Human IgM (µ chain), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to human IgG or IgA
AS10-1090
Agrisera AB
0,5 mg
EUR 233
Goat anti-Human IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine,mouse,rabbit serum
AS10-1157
Agrisera AB
0,5 mg
EUR 233
Goat anti-Rat IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to human, mouse IgG
AS10-1215
Agrisera AB
1 mg
EUR 233
Goat anti-Human IgM (µ chain), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to human IgG or IgA
AS10-1287
Agrisera AB
0,5 mg
EUR 259
Goat anti-Human IgM (µ chain), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to human IgA+IgG
AS10-1296
Agrisera AB
1 mg
EUR 233
Goat anti-Human IgM (µ chain), F(ab)'2 fragment, ALP conjugated, min, cross-reactivity to human IgG or IgA
AS10-1298
Agrisera AB
0,5 mg
EUR 273
Goat anti-Human IgG (H&L), F(ab)'2 fragment, ALP conjugated, min, cross-reactivity to bovine/mouse/rabbit serum
AS10-781
Agrisera AB
0,5 mg
EUR 206
Goat anti-Human IgG Fc, F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to bovine/mouse/rabbit serum
AS10-812
Agrisera AB
1 mg
EUR 233
Goat anti-Human IgM (µ chain), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to human IgG or IgA
AS10-959
Agrisera AB
0,5 mg
EUR 246
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to human IgG/serum
AS10-961
Agrisera AB
1 mg
EUR 233
Goat anti-Human IgM (µ chain), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to human IgG or IgA
AS10-979
Agrisera AB
0,5 mg
EUR 273
Goat anti-Human IgG Fc, F(ab)'2 Fragment, min, cross-reactivity to Human IgA/IgM, Bovine, Horse, Mouse, Rabbit Serum
AS16-3350
Agrisera AB
0,5 mg
EUR 216
Goat anti-Mouse IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG
AS16-3459
Agrisera AB
1,0 mg
EUR 284
Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovin, human, mouse IgG/serum
AS10-1042
Agrisera AB
0,5 mg
EUR 233
Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine,human, mouse IgG/serum
AS10-1059
Agrisera AB
0,5 mg
EUR 233
Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to human, mouse,Rat IgG
AS10-1077
Agrisera AB
1 mg
EUR 246
Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to bovine,human, mouse IgG/serum
AS10-1146
Agrisera AB
0,5 mg
EUR 233
Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to bovine,human, mouse IgG/serum
AS10-1153
Agrisera AB
0,5 mg
EUR 233
Goat anti-Rat IgG (H&L), F(ab)'2 fragment, DyLight® 488 conjugated, min, cross-reactivity to human, mouse lgG
AS10-1217
Agrisera AB
0,5 mg
EUR 259
Goat anti-Human IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to bovine/mouse/rabbit serum
AS10-780
Agrisera AB
1 mg
EUR 233
Goat anti-Rat IgG (H&L), F(ab)'2 fragment, DyLight® 550 conjugated, min, cross-reactivity to human, mouse lgG
AS12-1980
Agrisera AB
0,5 mg
EUR 246
Goat anti-Human IgG Fc, F(ab)'2 Fragment, min, cross-reactivity to bovine, horse, mouse or rabbit serum proteins, mouse IgG1
AS16-3356
Agrisera AB
1,0 mg
EUR 238
Goat anti-Mouse IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein
AS16-3461
Agrisera AB
1,0 mg
EUR 252
Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to bovine, human, mouse IgG/serum
AS10-982
Agrisera AB
1 mg
EUR 190
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 800 conjugated, min, cross-reactivity to human IgG or serum proteins
AS12-2436
Agrisera AB
0,5 mg
EUR 220
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, ALP conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG
AS16-3441
Agrisera AB
0,5 mg
EUR 264
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG
AS16-3445
Agrisera AB
0,5 mg
EUR 300
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG
AS16-3452
Agrisera AB
0,5 mg
EUR 284
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG
AS16-3456
Agrisera AB
0,5 mg
EUR 300
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG
AS16-3468
Agrisera AB
0,5 mg
EUR 284
Goat anti-Rabbit IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to non-immunoglobulin rabbit serum proteins and human serum proteins
AS16-3530
Agrisera AB
1,0 mg
EUR 203
Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, ALP (alkaline phosphatase) conjugated, min, cross-reactivity to bovine,human, mouse IgG/serum
AS10-1017
Agrisera AB
0,5 mg
EUR 233
Goat anti-Human IgG Fc, F(ab)'2 Fragment, FITC conjugated, min, cross-reactivity to bovine, horse, mouse or rabbit serum proteins, mouse IgG1
AS16-3354
Agrisera AB
0,5 mg
EUR 238
Goat anti-Human IgG Fc, F(ab)'2 Fragment, HRP conjugated, min, cross-reactivity to bovine, horse, mouse or rabbit serum proteins, mouse IgG1
AS16-3355
Agrisera AB
0,5 mg
EUR 245
Goat anti-Human IgG Fc, F(ab)'2 Fragment, TRITC conjugated, min, cross-reactivity to bovine, horse, mouse or rabbit serum proteins, mouse IgG1
AS16-3358
Agrisera AB
0,5 mg
EUR 275
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, ALP conjugated min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein
AS16-3440
Agrisera AB
0,5 mg
EUR 257
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin-conjugated, min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein
AS16-3462
Agrisera AB
0,5 mg
EUR 238
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein
AS16-3463
Agrisera AB
0,5 mg
EUR 214
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein
AS16-3464
Agrisera AB
0,5 mg
EUR 183
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein
AS16-3465
Agrisera AB
0,5 mg
EUR 214
Anti-EGFR (Ab-869) Antibody
Y021222
ABM
100 µg
EUR 285
Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, DyLight® 594 conjugated, min, cross-reactivity to bovine, human, or Mouse lgG or serum proteins
AS12-2083
Agrisera AB
0,5 mg
EUR 206
Goat anti-Rabbit IgG (H&L) -F(ab)'2 fragment, DyLight® 650 conjugated, min, cross-reactivity to bovine, human, or Mouse lgG or serum proteins
AS12-2337
Agrisera AB
0,5 mg
EUR 220
Goat anti-Mouse IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)
AS16-3460
Agrisera AB
1,0 mg
EUR 406
Donkey anti-Rabbit IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to Bovine, Chicken, Goat, Guinea Pig, Hamster, Horse, Human, Mouse, Rat or Sheep
AS16-3522
Agrisera AB
0,5 mg
EUR 213
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 550 conjugated,min, cross-reactivity to bovine, horse, human, pig or rabbit serum proteins
AS12-1945
Agrisera AB
0,5 mg
EUR 206
Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, DyLight® 550 conjugated,min, cross-reactivity to bovine, human, or Mouse lgG or serum proteins
AS12-1968
Agrisera AB
0,5 mg
EUR 206
Donkey anti-Mouse IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG
AS16-3458
Agrisera AB
0,5 mg
EUR 213
Goat anti-Mouse IgG (H&L), F(ab)'2 Fragment, ALP conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)
AS16-3442
Agrisera AB
0,5 mg
EUR 381
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)
AS16-3446
Agrisera AB
0,5 mg
EUR 442
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)
AS16-3457
Agrisera AB
0,5 mg
EUR 442
Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)
AS16-3469
Agrisera AB
0,5 mg
EUR 406
Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, ALP conjugate, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG
AS16-3439
Agrisera AB
0,5 mg
EUR 360
Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG
AS16-3444
Agrisera AB
0,5 mg
EUR 300
Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG
AS16-3451
Agrisera AB
0,5 mg
EUR 287
Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG
AS16-3455
Agrisera AB
0,5 mg
EUR 300
Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugate, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG
AS16-3466
Agrisera AB
0,5 mg
EUR 287
Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 633 conjugated, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG
AS12-2183
Agrisera AB
0,5 mg
EUR 334
NFκB-p100/p52 (Ab-869) Antibody
E021016-1
EnoGene
50μg/50μl
EUR 100
Description: Available in various conjugation types.
NFκB-p100/p52 (Ab-869) Antibody
E021016-2
EnoGene
100μg/100μl
EUR 170
Description: Available in various conjugation types.
anti-NFκB-p100/p52 (Ab-869)
LF-PA20318
Abfrontier
100 ul
EUR 400.8
Description: Rabbit polyclonal to NFκB-p100/p52
NF-kB p100/p52 (Ab-869)
ANTY021016
Antagene
100ug
EUR 259
NFkappaB-p100/p52 (Ab-869) Antibody
MBS856780-005mg
MyBiosource
0.05mg
EUR 190
NFkappaB-p100/p52 (Ab-869) Antibody
MBS856780-01mg
MyBiosource
0.1mg
EUR 255
NFkappaB-p100/p52 (Ab-869) Antibody
MBS856780-01mLAF405M
MyBiosource
0.1mL(AF405M)
EUR 465
NFkappaB-p100/p52 (Ab-869) Antibody
MBS856780-01mLAF546
MyBiosource
0.1mL(AF546)
EUR 465
NFkappaB-p100/p52 (Ab-869) Antibody
MBS856780-01mLAF750
MyBiosource
0.1mL(AF750)
EUR 465
NF-κB p100/p52 (Ab-869) Antibody
8B7165
AAT Bioquest
50ug
EUR 368
Description: NF-κB p100/p52 (Ab-869) Antibody
NF-κB p100/p52 (Ab-869) Antibody
E11-7165B
EnoGene
100μg/100μl
EUR 225
Description: Available in various conjugation types.
Polyclonal NF-KB p100 Antibody (Ab-869)
APR05373G
Leading Biology
0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NF-KB p100 (Ab-869). This antibody is tested and proven to work in the following applications:
NF-kappaB p100/p52 (Ab-869) Antibody
MBS8510216-01mg
MyBiosource
0.1mg
EUR 305
NF-kappaB p100/p52 (Ab-869) Antibody
MBS8510216-01mLAF405L
MyBiosource
0.1mL(AF405L)
EUR 465
NF-kappaB p100/p52 (Ab-869) Antibody
MBS8510216-01mLAF405S
MyBiosource
0.1mL(AF405S)
EUR 465
NF-kappaB p100/p52 (Ab-869) Antibody
MBS8510216-01mLAF610
MyBiosource
0.1mL(AF610)
EUR 465
NF-kappaB p100/p52 (Ab-869) Antibody
MBS8510216-01mLAF635
MyBiosource
0.1mL(AF635)
EUR 465
NF-KB p100/p52 Antibody (Ab-869)
MBS9212334-01mL
MyBiosource
0.1mL
EUR 425
NF-KB p100/p52 Antibody (Ab-869)
MBS9212334-5x01mL
MyBiosource
5x0.1mL
EUR 1887
Anti-Cardiac Troponin I Antibody
24001
Genovis AB
100ug
EUR 235
Anti-Cardiac Troponin I Antibody
24002
Genovis AB
100ug
EUR 235
Anti-DR3 (ED) Antibody
2401
Genovis AB
100ug
EUR 445
Anti-DR3 (NT) Antibody
2402
Genovis AB
100ug
EUR 445
Anti-DR3 (CT) Antibody
2403
Genovis AB
100ug
EUR 445
Anti-DR4 (CT) Antibody
2404
Genovis AB
100ug
EUR 445
Anti-RAIDD (CT) Antibody
2406
Genovis AB
100ug
EUR 445
Anti-FLIPγ/δ (CT) Antibody
2407
Genovis AB
100ug
EUR 445
Anti-Caspase-10 (CT) Antibody
2408
Genovis AB
100ug
EUR 445
Anti-DFF (CT) Antibody
2409
Genovis AB
100ug
EUR 445
Anti-DFF (NT) Antibody
2410
Genovis AB
100ug
EUR 445
The BDNF / TrkB pathway, when over expressed in tumors, correlate with reduced clinical prognosis and short life span of the patient. Targeting the BDNF / TrkB pathway and the use of Trk inhibitors, such as entrectinib, larotrectinib., A promising method for tumor targeted therapy. This review provides an overview of the role of TrkB pathway in the pathogenesis of cancer and its value as a potential therapeutic target.
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