MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress

MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress

Metabolic inflammation is associated with increased expression of a saturated free fatty acid, proinflammatory cytokines, chemokines, and adipose oxidative stress. Macrophage inflammatory protein (MIP) -1α recruit inflammatory cells such as monocytes, macrophages, and neutrophils in adipose tissue; However, the mechanism of promoting the expression of MIP-1α remains unclear.

We hypothesized that the co-induced by palmitate and tumor necrosis factor (TNF) -α in monocytic cells / macrophages can be further enhanced by the presence of reactive oxygen species (ROS) -mediated oxidative stress MIP-1α. To investigate this, THP-1 cells monocytic and human macrophages primary co-stimulated by palmitate and TNF-α and mRNA and protein levels of MIP-1α was measured by using transcription quantitative reverse, polymerase chain reaction (qRT-PCR) and commercial tests enzyme -linked immunosorbent assay (ELISA), respectively.

Cognate receptors of palmitic, pulses like receptor (TLR) -4, was blunted by genetic ablation, neutralization, and chemical inhibition. The involvement of TLR4-downstream pathway, interferon regulatory factor (IRF) -3 or myeloid differentiation (MYD) -88 factors, determined by using IRF3-siRNA or MyD88-deficient cells. induced oxidative stress in cells by hydrogen peroxide (H2O2) and ROS induction treatment was measured with dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay. Data show that MIP-1α gene expression / protein upregulated in cells co-stimulated by palmitate / TNF-α compared with those stimulated with either palmitic or TNF-α (P <0.05).

Furthermore, TLR4-IRF3 the pathway involved in cooperative induction of MIP-1α in THP-1 cells, and this kooperatititas between palmitate and TNF-α is a clathrin-dependent and is also required signal through the c-Jun and nuclear factor kappa-light- to medium-chain enhancer activated B cells (NF-kB). In particular, the ROS itself induced MIP-1α and could further promote the secretion of MIP-1α together with palmitate and TNF-α. In conclusion, palmitic and TNF-α co-induced MIP-1α in human monocytic cells via TLR4-IRF3 and signaling pathways involving c-Jun / NF-kB. Importantly, oxidative stress leads to ROS-driven amplification MIP-1α, which may have significance for inflammatory metabolism.

MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress
MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress

Progress in Regulating Cancer tumorigenicity and metastasis through TrkB signaling

Clinical Pathology various human malignancies supported by tropomyosin receptor kinase (Trk) B specific receptor TrkB which is derived neurotrophic factor from binding brain (BDNF) and TrkB .TrkB fusion protein has been observed for over-expressed in many cancer patients. In addition, they observed in several cell types. A multiple signaling pathways may be affected by abnormal activation pathway of BDNF / TrkB. These signaling pathways in-clude PI3K / Akt, transactivation of EGFR, phospholipase C-gamma (PLCγ) pathway, Ras-Raf-MEK-ERK pathway, Jak / STAT pathway, and nuclear factor kappa-light-chain-enhancer of B cells activated (NF-kB) pathway.

Abt-869

20-abx182361
  • EUR 1803.00
  • EUR 551.00
  • 100 mg
  • 10 mg

CK 869

B5788-10 10 mg
EUR 261

CK 869

B5788-25 25 mg
EUR 514

CK 869

B5788-5 5 mg
EUR 170

ABT-869

1615-1
EUR 213

ABT-869

1615-5
EUR 615

Linifanib (ABT-869)

E1KS1003 5mg
EUR 521

Linifanib (ABT-869)

A2949-100 100 mg
EUR 780
Description: Linifanib (ABT-869) is an effective ATP-competitive tyrosine kinase inhibitor against the platelet-derived growth factor (PDGF) receptor and the vascular endothelial growth factor receptor (VEGFR) families, including constitutively active FMS-like receptor tyrosine kinase 3 (FLT3) [1][2].

Linifanib (ABT-869)

A2949-25 25 mg
EUR 328
Description: Linifanib (ABT-869) is an effective ATP-competitive tyrosine kinase inhibitor against the platelet-derived growth factor (PDGF) receptor and the vascular endothelial growth factor receptor (VEGFR) families, including constitutively active FMS-like receptor tyrosine kinase 3 (FLT3) [1][2].

Linifanib (ABT-869)

A2949-5 5 mg
EUR 142
Description: Linifanib (ABT-869) is an effective ATP-competitive tyrosine kinase inhibitor against the platelet-derived growth factor (PDGF) receptor and the vascular endothelial growth factor receptor (VEGFR) families, including constitutively active FMS-like receptor tyrosine kinase 3 (FLT3) [1][2].

Linifanib (ABT-869)

A2949-5.1 10 mM (in 1mL DMSO)
EUR 195
Description: Linifanib (ABT-869) is an effective ATP-competitive tyrosine kinase inhibitor against the platelet-derived growth factor (PDGF) receptor and the vascular endothelial growth factor receptor (VEGFR) families, including constitutively active FMS-like receptor tyrosine kinase 3 (FLT3) [1][2].

HER2/neu (869-877)

5-01300 4 x 5mg Ask for price

HER2 / neu (869-877) Peptide

20-abx266601
  • EUR 398.00
  • EUR 244.00
  • EUR 314.00
  • 10 mg
  • 2 mg
  • 5 mg

OxiSelect Human Oxidized HDL ELISA Kit (MDA-HDL Quantitation)

STA-869 96 assays
EUR 780
Description: The OxiSelect Human Oxidized HDL ELISA Kits are enzyme immunoassays developed for the detection and quantitation of human oxHDL in plasma, serum or other biological fluid samples. This oxidized HDL assay kit is configured to selectively measure MDA-modified HDL. The kit contains an MDA-HDL standard against which unknown samples may be compared. Note: For samples stored for more than one month, better results may be obtained with measurement of CML or HNE modifications, both of which are more stable than MDA.

Recombinant (E.Coli, His-tag) Human Pancreatitis-Associated Protein-1

RP-869 10 ug
EUR 286

FABP8 Recombinant Protein

96-869 0.1 mg
EUR 490.25
Description: Myelin P2 protein (PMP2) is also known as peripheral myelin protein 2, which is a cytosolic protein found primarily in peripheral nerves. PMP2 is a small, basic, and cytoplasmic lipid binding protein of peripheral myelin. Also, PMP2 may play a role in lipid transport protein in Schwann cells. Furthermore, PMP2 may bind cholesterol.

Protein disulfide-isomerase A3 Recombinant Protein

91-869 0.05 mg
EUR 710.75
Description: PDIA3 protein is also known as Protein disulfide-isomerase A3. It is a protein that in humans is encoded by the PDIA3 gene.PDIA3 is an enzyme that belongs to the endoplasmic reticulum and interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. PDIA3 interacts with thiazide-sensitive sodium-chloride cotransporter in the kidney and is induced by glucose deprivation. PDIA3 is part of the major histocompatibility complex (MHC) class I peptide-loading complex (TAP1), which is important for formation of the final antigen conformation and export from the endoplasmic reticulum to the cell surface.

Recombinant Clostridium Acetobutylicum mutS Protein (aa 1-869)

VAng-Lsx7711-inquire inquire Ask for price
Description: Clostridium Acetobutylicum DNA mismatch repair protein MutS, recombinant protein.

96 WELL WHITE LOW PROFILE PCR MICROPLATE FOR AB

PCR-96-LP-AB-W 25/pk
EUR 388
Description: PCR Plates & Tubes; A354 PCR Plate-Axygen

Anti-CD4 (Keliximab)-MC-Vc-PAB-MMAE ADC

ADC-W-869 1mg Ask for price
Description: This ADC product is comprised of an anti-CD4 monoclonal antibody conjugated via a MC-Vc linker to MMAE

Recombinant Staphylococcus Aureus clpB Protein (aa 1-869) (strain MW2)

VAng-Cr5673-inquire inquire Ask for price
Description: Staphylococcus Aureus (strain MW2) Chaperone protein ClpB (clpB), recombinant protein.

Recombinant Staphylococcus Aureus clpB Protein (aa 1-869) (strain MRSA252)

VAng-Cr5674-inquire inquire Ask for price
Description: Staphylococcus Aureus (strain MRSA252) Chaperone protein ClpB (clpB), recombinant protein.

Recombinant Staphylococcus Aureus clpB Protein (aa 1-869) (strain N315)

VAng-Cr5675-inquire inquire Ask for price
Description: Staphylococcus Aureus (strain N315) Chaperone protein ClpB (clpB), recombinant protein.

AB-MECA

HY-19365 5mg
EUR 380

AB-423

HY-112142 100mg
EUR 2058

AB-680

HY-125286 10mg
EUR 1772

Soyasaponin Ab

HY-N3026 5mg
EUR 282

Activin AB

PR15011 5 ug
EUR 481

Mouse ACV-AB(Activin AB) ELISA Kit

EM0312 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

PDGF-AB/ Rat PDGF- AB ELISA Kit

ELA-E0112r 96 Tests
EUR 886

MBP-Ab/ Rat MBP- Ab ELISA Kit

ELA-E0170r 96 Tests
EUR 886

MC Ab/ Rat MC Ab ELISA Kit

ELA-E0390r 96 Tests
EUR 886

TPO-Ab/ Rat TPO- Ab ELISA Kit

ELA-E0442r 96 Tests
EUR 886

Thyroid Ab/ Rat Thyroid Ab ELISA Kit

ELA-E0844r 96 Tests
EUR 886

GNRHR-Ab/ Rat GNRHR- Ab ELISA Kit

ELA-E0962r 96 Tests
EUR 886

MAG Ab/ Rat MAG Ab ELISA Kit

ELA-E0995r 96 Tests
EUR 886

DNP-Ab/ Rat DNP- Ab ELISA Kit

ELA-E1122r 96 Tests
EUR 886

ENA-Ab/ Rat ENA- Ab ELISA Kit

ELA-E1124r 96 Tests
EUR 886

RNP-Ab/ Rat RNP- Ab ELISA Kit

ELA-E1129r 96 Tests
EUR 886

Ab Rabbit GluR2*

P40014-100uL 100uL Ask for price

Ab Rabbit MARCKS*

P40017-100uL 100uL Ask for price

Ab MS GluR1*

P80000-100uL 100uL Ask for price

Activin AB, CF

PR15011CF 5 ug
EUR 481

PDGF - AB Human

PR27062 2 ug
EUR 191

Human Serum AB

SC00B14 100 ml
EUR 362

AB-2950 MPEC

351201 5unit
EUR 279
Description: Super oxide(O2) reaction system L ight Emittingreagent

AB-2960 BactoLumix

3512020 2unit
EUR 315
Description: Menadione oxidation-reduction reaction system for probiotic measurement

AB-3000B Cellgraph

3600000 unit
EUR 100

Apoa5 (ab) Antibody

abx010415-100ul 100 ul
EUR 411

AB-Pinaca Antibody

abx023942-1mg 1 mg
EUR 620

AB-Pinaca Antibody

abx023943-1mg 1 mg
EUR 620

NGAL (Capture Ab)

20-abx019240
  • EUR 147.00
  • EUR 648.00
  • EUR 217.00
  • EUR 411.00
  • EUR 105.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50 ug

NGAL (Capture Ab)

20-abx019241
  • EUR 147.00
  • EUR 648.00
  • EUR 411.00
  • 100 ug
  • 1 mg
  • 500 ug

NGAL (Detection Ab)

abx019242-100ug 100 ug
EUR 648

rHu PDGF-AB

AK8282-0002 2µg Ask for price

rHu PDGF-AB

AK8282-0010 10µg Ask for price

rHu PDGF-AB

AK8282-0100 100µg Ask for price

rHu PDGF-AB

AK8282-1000 1mg Ask for price

Apoa5 (ab) Antibody

BF0615 200ul
EUR 376
Description: Apoa5 (ab) antibody detects endogenous levels of total Apoa5 (ab).

PDGF AB protein

30R-2610 10 ug
EUR 359
Description: Purified recombinant Human PDGF AB protein

PDGF AB protein

30R-AP003 10 ug
EUR 273
Description: Purified recombinant Human PDGF AB protein

Elk-1 Ab

3387-100
EUR 338

ELISA kit for Mouse ACV-AB (Activin AB)  Kit

E-EL-M2660 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Mouse ACV-AB (Activin AB)  Kit in samples from Serum, Plasma, Cell supernatant

n-DNA-Ab/ Rat n- DNA- Ab ELISA Kit

ELA-E1126r 96 Tests
EUR 886

Sc1-70-Ab/ Rat Sc1- 70- Ab ELISA Kit

ELA-E1131r 96 Tests
EUR 886

ACV-AB ELISA Kit| Mouse Activin AB ELISA Kit

EF012990 96 Tests
EUR 689

IFN-Gamma ab/ Rat IFN- Gamma ab ELISA Kit

ELA-E1716r 96 Tests
EUR 886

G-CSF ab/ Rat G- CSF ab ELISA Kit

ELA-E1717r 96 Tests
EUR 886

Goat Anti-Anthrax Edema Factor (B Anthracis) IgG-Biotinylated

EF11-AB 50 ug
EUR 408

Goat Anti-lethal factor (B Anthracis) IgG-biotinylated

LF16-AB 50 ug
EUR 408

Mouse monoclonal Anti-HA-tag peptide IgG

AB-10110 100 ug
EUR 469

Mouse Monoclonal Anti-Human Interleukin-2 IgG

AB-10210 100 ug
EUR 347

Rat Monoclonal Anti-Mouse Interleukin-2 receptor IgG

AB-10310 100 ug
EUR 347

Mouse Monoclonal Anti-Human Interleukin-2 receptor IgG

AB-10410 100 ug
EUR 347

Rat Monoclonal Anti-Mouse Interleukin-2 IgG

AB-10510 100 ug
EUR 347

Mouse Monoclonal Anti-Human Interleukin-3 IgG

AB-10610 100 ug
EUR 347

Mouse Monoclonal Anti-Human Interleukin-4 IgG

AB-10710 100 ug
EUR 347

Rat Monoclonal Anti-Mouse Interleukin-4 IgG

AB-10810 100 ug
EUR 347

Mouse Monoclonal Anti-Human Interleukin-6 IgG

AB-10910 100 ug
EUR 347

Mouse Monoclonal Anti-Human Interleukin-7 IgG

AB-11010 100 ug
EUR 347

Mouse Monoclonal Anti-Human Interleukin-8 IgG

AB-11110 100 ug
EUR 347

Mouse Monoclonal Anti-Human Interleukin-10 IgG

AB-11210 100 ug
EUR 347

Rat Monoclonal Anti-Mouse Interleukin-10 IgG

AB-11310 100 ug
EUR 347

Rat Monoclonal Anti-Mouse Interleukin-12p40 IgG

AB-11410 100 ug
EUR 347

Mouse Monoclonal Anti-Human Interleukin-15 IgG

AB-11510 100 ug
EUR 347

Hamster Mono Anti-Mouse CTLA-4 (CD152) IgG

AB-11610 100 ug
EUR 347

Mouse Monoclonal Anti-Human Eotaxin-1 (CCL11) IgG

AB-12610 100 ug
EUR 347

Mouse Monoclonal Anti-Chlamydia LPS IgG

AB-13010 100 ug
EUR 347

Mouse Monoclonal Anti-Human CD8-FITC IgG

AB-13110 100 ug
EUR 347

Mouse Monoclonal Anti-Human CD4-FITC IgG

AB-13210 100 ug
EUR 347

Rat Monoclonal Anti-Mouse CD80 IgG

AB-13310 100 ug
EUR 347

Mouse Monoclonal Anti-Human CD8-biotinylated IgG

AB-13410 100 ug
EUR 347

Rat Monoclonal Anti-Mouse CD11a IgG

AB-13510 100 ug
EUR 347

Rat Monoclonal Anti-Mouse CD11b-FITC IgG

AB-13610 100 ug
EUR 347

Mouse Monoclonal Anti-Human CD3-FITC IgG

AB-13710 100 ug
EUR 347

Mouse Monoclonal Anti-Human CD3-biotinylated IgG

AB-13810 100 ug
EUR 347

Rat Monoclonal Anti-Mouse B220 (CD45R) IgG

AB-13910 100 ug
EUR 347

Rat Monoclonal Anti-Mouse CD90 Thy-1.1 IgG

AB-14010 100 ug
EUR 347

Rat Monoclonal Anti-Mouse CD90 Thy-1.2 IgG

AB-14110 100 ug
EUR 347

Rat Monoclonal Anti-Mouse CD90 Thy-1 IgG

AB-14210 100 ug
EUR 347

Mouse Monoclonal Anti-Dengue Virus Type 2 envelop IgG, aff pure

AB-14310 100 ug
EUR 347

Mouse monoclonal Anti-Human CD3 IgG, unlabled

AB-14410 100 ug
EUR 469

Mouse Monoclonal Anti-Human CD4 IgG

AB-14510 100 ug
EUR 347

Mouse Monoclonal Anti-Human CD8 IgG

AB-14810 100 ug
EUR 347

Mouse Monoclonal Anti-Hepatitis B Virus (HBsAg;AD & AY Antigens) IgG

AB-15010 100 ug
EUR 347

Mouse Monoclonal Anti-HIV-1 gp120 (PND, principal neutralizing domain) IgG

AB-15110 100 ug
EUR 347

Mouse Monoclonal Anti- HIV-1 p24 IgG

AB-15210 100 ug
EUR 347

Mouse Monoclonal Anti-HIV-2 gp39 IgG

AB-15310 100 ug
EUR 347

Mouse Monoclonal Anti-Hepatitis C Virus (HCV) NS3 IgG

AB-15610 20 ug
EUR 408

Mouse Monoclonal Anti-SARS Spike Protein IgG

AB-15710 20 ug
EUR 408

Mouse Monoclonal Anti-HIV-1 gp41 IgG

AB-15910 100 ug
EUR 347

Rabbit Anti-HIV-1 gp41 IgG

AB-16010 1 ml
EUR 347

Mouse Monoclonal Anti-HIV-2 gp39 IgG

AB-16110 1 ml
EUR 347

Mouse monoclonal Anti-HIV-2 p17 IgG

AB-16120 100 ug
EUR 469

Goat Anti-HIV Virus/Virion IgG (poly)

AB-16130 100 ul
EUR 445

Goat Anti-HIV p24 IgG (poly)

AB-16140 100 ul
EUR 445

Goat Anti-HIV gp120 IgG (poly) IgG

AB-16150 100 ul
EUR 445

Goat Anti-HIV gp41 IgG (poly) IgG

AB-16160 100 ul
EUR 445

Mouse Monoclonal Anti-Hepatitis B Surface Antigen A (HBsAg) IgG

AB-16310 1 ml
EUR 347

Rat Monoclonal Anti-Mouse CD4 IgG

AB-16510 100 ug
EUR 347

Rat Monoclonal Anti-Mouse IFN-gamma IgG

AB-16610 100 ug
EUR 347

Mouse Monoclonal Anti-Human CD4-biotinylated IgG

AB-16710 100 ug
EUR 347

Mouse Monoclonal Anti-Human CD5 IgG

AB-17110 100 ug
EUR 347

Rat Monoclonal Anti-Mouse CD3 IgG

AB-17510 100 ug
EUR 347

Mouse Monoclonal Anti-SARS Nucleocapsid protein IgG

AB-17810 50 ug
EUR 469

Mouse Monoclonal Anti-SARS Spike IgG

AB-17910 50 ug
EUR 469

Mouse Monoclonal Anti-SARS Nucleocapsid Protein IgG

AB-18010 50 ug
EUR 469

Mouse Monoclonal Anti-Myelin Oligodendrocyte Glycoprotein IgG

AB-19910 100 ug
EUR 347

Mouse Monoclonal Anti-Human FAS (CD95) Blocking antibody IgG

AB-20410 100 ug
EUR 347

Mouse Monoclonal Anti-Human FAS (CD95) Activating antibody IgG

AB-20510 100 ug
EUR 347

Mouse Monoclonal Anti-Human CD1A (T6, LEU6) IgG

AB-20610 100 ug
EUR 347

Mouse Monoclonal Anti-Human CD2 (T11, LFA-2) IgG

AB-20710 100 ug
EUR 347

Rat Monoclonal Anti-Mouse Interleukin-12p75 IgG

AB-20910 100 ug
EUR 347

Rabbit Anti HIV-1 gp120

AB-21010 50 ul
EUR 408

Mouse Monoclonal Anti-Human c-Myc IgG

AB-21110 100 ug
EUR 347

Monoclonal Anti-Dengue Virus Type 1-4 (pan, E antigen) IgG, culture medium

AB-21121 0.5 ml
EUR 529

Monoclonal Anti-Dengue Virus Type 2, NS1 IgG

AB-21123 100 ul
EUR 445

Monoclonal Anti-Human Thiopurine S-methyltransferase (TPMT) protein IgG

AB-22123 5 ug
EUR 164

Rabbit Anti-Human Interleukin 6 receptor (IL-6RCD126, gp80/IL-6RA)

AB-22124 50 ul
EUR 469

Human Platelet-Derived Growth Factor AB, PDGF-AB ELISA kit

CSB-E04701h-24T 1 plate of 24 wells
EUR 165
Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor AB, PDGF-AB in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Platelet-Derived Growth Factor AB, PDGF-AB ELISA kit

1-CSB-E04701h
  • EUR 723.00
  • EUR 4883.00
  • EUR 2591.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor AB, PDGF-AB in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Platelet-Derived Growth Factor AB, PDGF-AB ELISA kit

CSB-E04703r-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Rat Platelet-Derived Growth Factor AB, PDGF-AB in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Platelet-Derived Growth Factor AB, PDGF-AB ELISA kit

1-CSB-E04703r
  • EUR 703.00
  • EUR 4843.00
  • EUR 2570.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Platelet-Derived Growth Factor AB, PDGF-AB in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Pig Platelet-Derived Growth Factor AB (PDGF-AB) ELISA kit

CSB-EQ027978PI-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Pig Platelet-Derived Growth Factor AB (PDGF-AB) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Pig Platelet-Derived Growth Factor AB (PDGF-AB) ELISA kit

1-CSB-EQ027978PI
  • EUR 900.00
  • EUR 5476.00
  • EUR 2900.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Pig Platelet-Derived Growth Factor AB (PDGF-AB) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rabbit Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

CSB-E15910Rb-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Rabbit Platelet-Derived Growth Factor AB (PDGF-AB) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rabbit Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

1-CSB-E15910Rb
  • EUR 703.00
  • EUR 4843.00
  • EUR 2570.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rabbit Platelet-Derived Growth Factor AB(PDGF-AB) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

GA-E0148MS-48T 48T
EUR 336

Mouse Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

GA-E0148MS-96T 96T
EUR 534

Rat Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

GA-E0700RT-48T 48T
EUR 373

Rat Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

GA-E0700RT-96T 96T
EUR 609

Human Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

GA-E0076HM-48T 48T
EUR 289

Human Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

GA-E0076HM-96T 96T
EUR 466

Human Platelet-Derived Growth Factor AB,PDGF-AB ELISA kit

201-12-0138 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Platelet Derived Growth Factor AB (PDGF-AB) CLIA Kit

abx197488-96tests 96 tests
EUR 825

Rat Platelet-Derived Growth Factor AB (PDGF-AB) CLIA Kit

abx197512-96tests 96 tests
EUR 825

Rabbit PDGF-AB(Platelet Derived Growth Factor AB) ELISA Kit

ERB0095 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rabbit;Sensitivity: 0.938 ng/ml

Rat Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

QY-E10952 96T
EUR 361

Mouse Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

QY-E21208 96T
EUR 361

Human Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

QY-E00586 96T
EUR 400

Human PDGF-AB(Platelet-Derived Growth Factor AB) ELISA Kit

EH0139 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Rat PDGF-AB(Platelet-Derived Growth Factor AB) ELISA Kit

ER0056 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 4.688pg/ml

Mouse Platelet-Derived Growth Factor AB,PDGF-AB ELISA kit

CN-02423M1 96T
EUR 457

Mouse Platelet-Derived Growth Factor AB,PDGF-AB ELISA kit

CN-02423M2 48T
EUR 306

Human Platelet-Derived Growth Factor AB,PDGF-AB ELISA kit

CN-03255H1 96T
EUR 467

Human Platelet-Derived Growth Factor AB,PDGF-AB ELISA kit

CN-03255H2 48T
EUR 316

Rat Platelet-Derived Growth Factor AB,PDGF-AB ELISA kit

CN-01590R1 96T
EUR 457

Rat Platelet-Derived Growth Factor AB,PDGF-AB ELISA kit

CN-01590R2 48T
EUR 306

SF1 (Ab-82) Antibody

CSB-PA963117-
EUR 335
Description: A polyclonal antibody against SF1 (Ab-82). Recognizes SF1 (Ab-82) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500

SF1 (Ab-82) Antibody

CSB-PA963117-100ul 100ul
EUR 316
Description: A polyclonal antibody against SF1 (Ab-82). Recognizes SF1 (Ab-82) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500

TP53 (Ab-315) Antibody

CSB-PA964395-
EUR 335
Description: A polyclonal antibody against TP53 (Ab-315). Recognizes TP53 (Ab-315) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

TP53 (Ab-315) Antibody

CSB-PA964395-100ul 100ul
EUR 316
Description: A polyclonal antibody against TP53 (Ab-315). Recognizes TP53 (Ab-315) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

MAP2K1 (Ab-291) Antibody

CSB-PA965933-
EUR 335
Description: A polyclonal antibody against MAP2K1 (Ab-291). Recognizes MAP2K1 (Ab-291) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:200

MAP2K1 (Ab-291) Antibody

CSB-PA965933-100ul 100ul
EUR 316
Description: A polyclonal antibody against MAP2K1 (Ab-291). Recognizes MAP2K1 (Ab-291) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:200

AKT1 (Ab-450) Antibody

CSB-PA969941-
EUR 335
Description: A polyclonal antibody against AKT1 (Ab-450). Recognizes AKT1 (Ab-450) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

AKT1 (Ab-450) Antibody

CSB-PA969941-100ul 100ul
EUR 316
Description: A polyclonal antibody against AKT1 (Ab-450). Recognizes AKT1 (Ab-450) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

CBX5 (Ab-92) Antibody

CSB-PA971900-
EUR 335
Description: A polyclonal antibody against CBX5 (Ab-92). Recognizes CBX5 (Ab-92) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

CBX5 (Ab-92) Antibody

CSB-PA971900-100ul 100ul
EUR 316
Description: A polyclonal antibody against CBX5 (Ab-92). Recognizes CBX5 (Ab-92) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

CCNB1 (Ab-147) Antibody

CSB-PA973969-
EUR 335
Description: A polyclonal antibody against CCNB1 (Ab-147). Recognizes CCNB1 (Ab-147) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

CCNB1 (Ab-147) Antibody

CSB-PA973969-100ul 100ul
EUR 316
Description: A polyclonal antibody against CCNB1 (Ab-147). Recognizes CCNB1 (Ab-147) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

STAT2 (Ab-690) Antibody

CSB-PA974482-
EUR 335
Description: A polyclonal antibody against STAT2 (Ab-690). Recognizes STAT2 (Ab-690) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:200

STAT2 (Ab-690) Antibody

CSB-PA974482-100ul 100ul
EUR 316
Description: A polyclonal antibody against STAT2 (Ab-690). Recognizes STAT2 (Ab-690) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:200

FADD (Ab-191) Antibody

CSB-PA975869-
EUR 335
Description: A polyclonal antibody against FADD (Ab-191). Recognizes FADD (Ab-191) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

FADD (Ab-191) Antibody

CSB-PA975869-100ul 100ul
EUR 316
Description: A polyclonal antibody against FADD (Ab-191). Recognizes FADD (Ab-191) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

LCK (Ab-394) Antibody

CSB-PA977883-
EUR 335
Description: A polyclonal antibody against LCK (Ab-394). Recognizes LCK (Ab-394) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

LCK (Ab-394) Antibody

CSB-PA977883-100ul 100ul
EUR 316
Description: A polyclonal antibody against LCK (Ab-394). Recognizes LCK (Ab-394) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

SMAD2 (Ab-465) Antibody

CSB-PA981649-
EUR 335
Description: A polyclonal antibody against SMAD2 (Ab-465). Recognizes SMAD2 (Ab-465) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

SMAD2 (Ab-465) Antibody

CSB-PA981649-100ul 100ul
EUR 316
Description: A polyclonal antibody against SMAD2 (Ab-465). Recognizes SMAD2 (Ab-465) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

DPYSL2 (Ab-522) Antibody

CSB-PA982099-
EUR 335
Description: A polyclonal antibody against DPYSL2 (Ab-522). Recognizes DPYSL2 (Ab-522) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

DPYSL2 (Ab-522) Antibody

CSB-PA982099-100ul 100ul
EUR 316
Description: A polyclonal antibody against DPYSL2 (Ab-522). Recognizes DPYSL2 (Ab-522) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

The BDNF / TrkB pathway, when over expressed in tumors, correlate with reduced clinical prognosis and short life span of the patient. Targeting the BDNF / TrkB pathway and the use of Trk inhibitors, such as entrectinib, larotrectinib., A promising method for tumor targeted therapy. This review provides an overview of the role of TrkB pathway in the pathogenesis of cancer and its value as a potential therapeutic target.

Tony

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