Metabolic inflammation is associated with increased expression of a saturated free fatty acid, proinflammatory cytokines, chemokines, and adipose oxidative stress. Macrophage inflammatory protein (MIP) -1α recruit inflammatory cells such as monocytes, macrophages, and neutrophils in adipose tissue; However, the mechanism of promoting the expression of MIP-1α remains unclear.
We hypothesized that the co-induced by palmitate and tumor necrosis factor (TNF) -α in monocytic cells / macrophages can be further enhanced by the presence of reactive oxygen species (ROS) -mediated oxidative stress MIP-1α. To investigate this, THP-1 cells monocytic and human macrophages primary co-stimulated by palmitate and TNF-α and mRNA and protein levels of MIP-1α was measured by using transcription quantitative reverse, polymerase chain reaction (qRT-PCR) and commercial tests enzyme -linked immunosorbent assay (ELISA), respectively.
Cognate receptors of palmitic, pulses like receptor (TLR) -4, was blunted by genetic ablation, neutralization, and chemical inhibition. The involvement of TLR4-downstream pathway, interferon regulatory factor (IRF) -3 or myeloid differentiation (MYD) -88 factors, determined by using IRF3-siRNA or MyD88-deficient cells. induced oxidative stress in cells by hydrogen peroxide (H2O2) and ROS induction treatment was measured with dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay. Data show that MIP-1α gene expression / protein upregulated in cells co-stimulated by palmitate / TNF-α compared with those stimulated with either palmitic or TNF-α (P <0.05).
Furthermore, TLR4-IRF3 the pathway involved in cooperative induction of MIP-1α in THP-1 cells, and this kooperatititas between palmitate and TNF-α is a clathrin-dependent and is also required signal through the c-Jun and nuclear factor kappa-light- to medium-chain enhancer activated B cells (NF-kB). In particular, the ROS itself induced MIP-1α and could further promote the secretion of MIP-1α together with palmitate and TNF-α. In conclusion, palmitic and TNF-α co-induced MIP-1α in human monocytic cells via TLR4-IRF3 and signaling pathways involving c-Jun / NF-kB. Importantly, oxidative stress leads to ROS-driven amplification MIP-1α, which may have significance for inflammatory metabolism.
MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress
Progress in Regulating Cancer tumorigenicity and metastasis through TrkB signaling
Clinical Pathology various human malignancies supported by tropomyosin receptor kinase (Trk) B specific receptor TrkB which is derived neurotrophic factor from binding brain (BDNF) and TrkB .TrkB fusion protein has been observed for over-expressed in many cancer patients. In addition, they observed in several cell types. A multiple signaling pathways may be affected by abnormal activation pathway of BDNF / TrkB. These signaling pathways in-clude PI3K / Akt, transactivation of EGFR, phospholipase C-gamma (PLCγ) pathway, Ras-Raf-MEK-ERK pathway, Jak / STAT pathway, and nuclear factor kappa-light-chain-enhancer of B cells activated (NF-kB) pathway.
EGFR (Ab-869) Antibody
CSB-PA877124-100ul
Cusabio
100ul
EUR 379.2
Description: A polyclonal antibody against EGFR (Ab-869). Recognizes EGFR (Ab-869) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:200
EGFR (Ab-869) Antibody
8B7065
AAT Bioquest
50ug
EUR 368
Description: EGFR (Ab-869) Antibody
anti-EGFR (Ab-869)
LF-PA20123
Abfrontier
100 ul
EUR 400.8
Description: Rabbit polyclonal to EGFR
Anti-EGFR (Ab-869) Antibody
Y021222
ABM
100 µg
EUR 285
NFκB-p100/p52 (Ab-869) Antibody
E021016-1
EnoGene
50μg/50μl
EUR 100
Description: Available in various conjugation types.
NFκB-p100/p52 (Ab-869) Antibody
E021016-2
EnoGene
100μg/100μl
EUR 170
Description: Available in various conjugation types.
anti-NFκB-p100/p52 (Ab-869)
LF-PA20318
Abfrontier
100 ul
EUR 400.8
Description: Rabbit polyclonal to NFκB-p100/p52
NF-kB p100/p52 (Ab-869)
ANTY021016
Antagene
100ug
EUR 259
Apolipoprotein E2, (ApoE2) (1mg) Human Recombinant
AE-100-10
AlexoTech AB
1 mg
EUR 330
Apolipoprotein E3, (ApoE3) (1mg) Human Recombinant
AE-101-10
AlexoTech AB
1 mg
EUR 330
Apolipoprotein E4, (ApoE4) (1mg) Human Recombinant
AE-102-10
AlexoTech AB
1 mg
EUR 330
Apolipoprotein E4, (ApoE4) (1mg) 1-199 Human Recombinant
AE-103-10
AlexoTech AB
1 mg
EUR 330
Apolipoprotein E4, (ApoE4) (1mg) 1-162 Human Recombinant
AE-104-10
AlexoTech AB
1 mg
EUR 330
Apolipoprotein E4, (ApoE4) (1mg) 1-132 Human Recombinant
AE-105-10
AlexoTech AB
1 mg
EUR 330
Alpha-Synuclein (1.0 mg) Human, Recombinant
AS-600-10
AlexoTech AB
1 mg
EUR 170.5
Alpha-Synuclein (10x 1mg) Human, Recombinant
AS-600-100
AlexoTech AB
10 X 1.0mg
EUR 1358.5
Alpha-Synuclein (50x 1mg) Human, Recombinant
As-600-500
AlexoTech AB
50 X 1.0mg
EUR 5967.5
Alpha-Synuclein 1-120 (1.0 mg) Human, Recombinant
AS-602-10
AlexoTech AB
1 mg
EUR 170.5
Alpha-Synuclein (A30P) (1.0 mg) Human, Recombinant
AS-603-10
AlexoTech AB
1 mg
EUR 247.5
Alpha-Synuclein (A53T) (1.0 mg) Human, Recombinant
AS-604-10
AlexoTech AB
1 mg
EUR 247.5
Alpha-Synuclein (E46K) (1.0 mg) Human, Recombinant
AS-605-10
AlexoTech AB
1 mg
EUR 247.5
Alpha-Synuclein (1.0 mg) Mouse, Recombinant
AS-650-10
AlexoTech AB
1 mg
EUR 170.5
Mouse IgG Anti-Transthyretin (39-44) (Amyloid Specific) 100 ug
AT-550-01
AlexoTech AB
100 ug
EUR 357.5
Mouse IgG Anti-Transthyretin (56-61) (Amyloid Specific) 100 ug
AT-560-01
AlexoTech AB
100 ug
EUR 357.5
Transthyretin (Wild Type) (10 X 1.0mg) Human, Recombinant
T-500-10
AlexoTech AB
1 mg
EUR 1628
Transthyretin (L12P) (1.0 mg) Human, Recombinant
T-501-10
AlexoTech AB
1 mg
EUR 330
Transthyretin (V30G) (1.0 mg) Human, Recombinant
T-502-10
AlexoTech AB
1 mg
EUR 247.5
Transthyretin (A36P) (1.0 mg) Human, Recombinant
T-503-10
AlexoTech AB
1 mg
EUR 330
Transthyretin (D18G) (1.0 mg) Human, Recombinant
T-504-10
AlexoTech AB
1 mg
EUR 330
Transthyretin (V30M) (1.0 mg) Human, Recombinant
T-505-10
AlexoTech AB
1 mg
EUR 247.5
Transthyretin (G53E) (1.0 mg) Human, Recombinant
T-506-10
AlexoTech AB
1 mg
EUR 247.5
Transthyretin (V122I) (1.0 mg) Human, Recombinant
T-507-10
AlexoTech AB
1 mg
EUR 247.5
Transthyretin (F87M/L110M) (1.0mg), Human, Recombinant
T-509-10
AlexoTech AB
1 mg
EUR 247.5
Transthyretin (L55P) (1.0 mg) Human, Recombinant
T-510-10
AlexoTech AB
1 mg
EUR 247.5
Transthyretin (F64S) (1.0mg), Human, Recombinant
T-511-10
AlexoTech AB
1 mg
EUR 247.5
Transthyretin (Y69H) (1.0 mg) Human, Recombinant
T-512-10
AlexoTech AB
1 mg
EUR 247.5
Transthyretin (T119M) (1.0 mg) Human, Recombinant
T-515-10
AlexoTech AB
1 mg
EUR 247.5
Transthyretin (T60A) (1.0mg) Human, Recombinant
T-516-10
AlexoTech AB
1 mg
EUR 330
Transthyretin (A97S) (1.0mg) Human, Recombinant
T-517-10
AlexoTech AB
1 mg
EUR 330
Transthyretin (S52P) (1.0 mg) Human, Recombinant
T-518-10
AlexoTech AB
1 mg
EUR 247.5
Transthyretin (L111M) (1.0 mg) Human, Recombinant
T-519-10
AlexoTech AB
1 mg
EUR 247.5
Transthyretin (V30I) (1.0 mg) Human, Recombinant
T-535-10
AlexoTech AB
1 mg
EUR 247.5
ELISA Flex: Bovine TNF-alpha (ALP)
3012-1A-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Bovine TNF-alpha (ALP)
3012-1A-6
Mabtech AB
for 6 plates
EUR 351.75
ELISA Flex: Bovine TNF-alpha (HRP)
3012-1H-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Bovine TNF-alpha (HRP)
3012-1H-6
Mabtech AB
for 6 plates
EUR 351.75
ELISpot Flex: Bovine TNF-alpha (ALP)
3012-2A
Mabtech AB
for 4 plates
EUR 609
ELISpot Flex: Bovine TNF-alpha (HRP)
3012-2H
Mabtech AB
for 4 plates
EUR 609
Anti-bovine TNF-alpha mAb (MTF4918), unconjugated
3012-3-1000
Mabtech AB
1 mg
EUR 840
Anti-bovine TNF-alpha mAb (MTF4918), unconjugated
3012-3-250
Mabtech AB
250 µg
EUR 241.5
ELISpot Plus: Bovine TNF-alpha (ALP)
3012-4APW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Bovine TNF-alpha (ALP)
3012-4APW-2
Mabtech AB
2 plates
EUR 535.5
ELISpot Plus Bovine TNF-alpha (HRP)
3012-4HPW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus Bovine TNF-alpha (HRP)
3012-4HPW-2
Mabtech AB
2 plates
EUR 535.5
Anti-bovine TNF-alpha mAb (MT771), biotin
3012-6-1000
Mabtech AB
1 mg
EUR 1044.75
Anti-bovine TNF-alpha mAb (MT771), biotin
3012-6-250
Mabtech AB
250 µg
EUR 283.5
ELISA Flex: Porcine IL-17A (ALP)
3020-1A-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Porcine IL-17A (ALP)
3020-1A-6
Mabtech AB
for 6 plates
EUR 351.75
ELISA Flex: Porcine IL-17A (HRP)
3020-1H-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Porcine IL-17A (HRP)
3020-1H-6
Mabtech AB
for 6 plates
EUR 351.75
ELISpot Flex: Porcine IL-17A (ALP)
3020-2A
Mabtech AB
for 4 plates
EUR 609
ELISpot Flex: Porcine IL-17A (HRP)
3020-2H
Mabtech AB
for 4 plates
EUR 609
ELISpot Plus: Porcine IL-17A (ALP)
3020-4APW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Porcine IL-17A (ALP)
3020-4APW-2
Mabtech AB
2 plates
EUR 535.5
ELISpot Plus: Porcine IL-17A (HRP)
3020-4HPW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Porcine IL-17A (HRP)
3020-4HPW-2
Mabtech AB
2 plates
EUR 535.5
Anti-porcine IL-17A mAb (MTP853), biotin
3020-6-1000
Mabtech AB
1 mg
EUR 1044.75
Anti-porcine IL-17A mAb (MTP853), biotin
3020-6-250
Mabtech AB
250 µg
EUR 283.5
ELISpot Flex: Woodchuck IFN-gamma (ALP)
3101-2A
Mabtech AB
for 4 plates
EUR 609
ELISpot Flex: Woodchuck IFN-gamma (HRP)
3101-2H
Mabtech AB
for 4 plates
EUR 609
Anti-woodchuck IFN-gamma mAb (MT247), unconjugated
3101-3-1000
Mabtech AB
1 mg
EUR 840
Anti-woodchuck IFN-gamma mAb (MT247), unconjugated
3101-3-250
Mabtech AB
250 µg
EUR 241.5
Anti-woodchuck IFN-gamma mAb (MT225), biotin
3101-6-1000
Mabtech AB
1 mg
EUR 1044.75
Anti-woodchuck IFN-gamma mAb (MT225), biotin
3101-6-250
Mabtech AB
250 µg
EUR 283.5
ELISA Flex: Hamster IFN-gamma (ALP)
3102-1A-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Hamster IFN-gamma (ALP)
3102-1A-6
Mabtech AB
for 6 plates
EUR 351.75
ELISA Flex: Hamster IFN-gamma (HRP)
3102-1H-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Hamster IFN-gamma (HRP)
3102-1H-6
Mabtech AB
for 6 plates
EUR 351.75
ELISpot Flex: Hamster IFN-gamma (ALP)
3102-2A
Mabtech AB
for 4 plates
EUR 609
ELISpot Flex: Hamster IFN-gamma (HRP)
3102-2H
Mabtech AB
for 4 plates
EUR 609
Anti-hamster IFN-gamma mAb (MTH21), unconjugated
3102-3-1000
Mabtech AB
1 mg
EUR 840
Anti-hamster IFN-gamma mAb (MTH21), unconjugated
3102-3-250
Mabtech AB
250 µg
EUR 241.5
ELISpot Plus: Hamster IFN-gamma (ALP)
3102-4APW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Hamster IFN-gamma (ALP)
3102-4APW-2
Mabtech AB
2 plates
EUR 535.5
ELISpot Plus: Hamster IFN-gamma (HRP)
3102-4HPW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Hamster IFN-gamma (HRP)
3102-4HPW-2
Mabtech AB
2 plates
EUR 535.5
Anti-hamster IFN-gamma mAb (MTH29), biotin
3102-6-1000
Mabtech AB
1 mg
EUR 1044.75
Anti-hamster IFN-gamma mAb (MTH29), biotin
3102-6-250
Mabtech AB
250 µg
EUR 283.5
Anti-ferret IL-2 mAb (MT264), unconjugated
3104-1-1000
Mabtech AB
1 mg
EUR 840
Anti-ferret IL-2 mAb (MT264), unconjugated
3104-1-250
Mabtech AB
250 µg
EUR 241.5
ELISA Flex: Ferret IL-2 (ALP)
3104-1A-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Ferret IL-2 (ALP)
3104-1A-6
Mabtech AB
for 6 plates
EUR 351.75
ELISA Flex: Ferret IL-2 (HRP)
3104-1H-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Ferret IL-2 (HRP)
3104-1H-6
Mabtech AB
for 6 plates
EUR 351.75
ELISpot Flex: Ferret IL-2 (ALP)
3104-2A
Mabtech AB
for 4 plates
EUR 609
ELISpot Flex: Ferret IL-2 (HRP)
3104-2H
Mabtech AB
for 4 plates
EUR 609
Anti-ferret IL-2 mAbs (MT264/271), unconjugated
3104-3-1000
Mabtech AB
1 mg
EUR 840
Anti-ferret IL-2 mAbs (MT264/271), unconjugated
3104-3-250
Mabtech AB
250 µg
EUR 241.5
ELISA Flex: Bovine IL-17A (ALP)
3109-1A-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Bovine IL-17A (ALP)
3109-1A-6
Mabtech AB
for 6 plates
EUR 351.75
ELISA Flex: Bovine IL-17A (HRP)
3109-1H-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Bovine IL-17A (HRP)
3109-1H-6
Mabtech AB
for 6 plates
EUR 351.75
ELISpot Flex: Bovine IL-17A (ALP)
3109-2A
Mabtech AB
for 4 plates
EUR 609
ELISpot Flex: Bovine IL-17A (HRP)
3109-2H
Mabtech AB
for 4 plates
EUR 609
Anti-bovine IL-17A mAb (MT49A7), unconjugated
3109-3-1000
Mabtech AB
1 mg
EUR 840
Anti-bovine IL-17A mAb (MT49A7), unconjugated
3109-3-250
Mabtech AB
250 µg
EUR 241.5
ELISpot Plus: Bovine IL-17A (ALP)
3109-4APW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Bovine IL-17A (ALP)
3109-4APW-2
Mabtech AB
2 plates
EUR 535.5
ELISpot Plus: Bovine IL-17A (HRP)
3109-4HPW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Bovine IL-17A (HRP)
3109-4HPW-2
Mabtech AB
2 plates
EUR 535.5
Anti-bovine IL-17A mAb (MT51B8), biotin
3109-6-1000
Mabtech AB
1 mg
EUR 1044.75
Anti-bovine IL-17A mAb (MT51B8), biotin
3109-6-250
Mabtech AB
250 µg
EUR 283.5
ELISA Flex: Rabbit IFN-gamma (ALP)
3110-1A-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Rabbit IFN-gamma (ALP)
3110-1A-6
Mabtech AB
for 6 plates
EUR 351.75
ELISA Flex: Rabbit IFN-gamma (HRP)
3110-1H-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Rabbit IFN-gamma (HRP)
3110-1H-6
Mabtech AB
for 6 plates
EUR 351.75
ELISpot Flex: Rabbit IFN-gamma (ALP)
3110-2A
Mabtech AB
for 4 plates
EUR 609
ELISpot Flex: Rabbit IFN-gamma (HRP)
3110-2H
Mabtech AB
for 4 plates
EUR 609
Anti-rabbit IFN-gamma mAb (MT327), unconjugated
3110-3-1000
Mabtech AB
1 mg
EUR 840
Anti-rabbit IFN-gamma mAb (MT327), unconjugated
3110-3-250
Mabtech AB
250 µg
EUR 241.5
ELISpot Plus: Rabbit IFN-gamma (ALP)
3110-4APW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Rabbit IFN-gamma (ALP)
3110-4APW-2
Mabtech AB
2 plates
EUR 535.5
ELISpot Plus: Rabbit IFN-gamma (HRP)
3110-4HPW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Rabbit IFN-gamma (HRP)
3110-4HPW-2
Mabtech AB
2 plates
EUR 535.5
Anti-rabbit IFN-gamma mAb (MT318), biotin
3110-6-1000
Mabtech AB
1 mg
EUR 1044.75
Anti-rabbit IFN-gamma mAb (MT318), biotin
3110-6-250
Mabtech AB
250 µg
EUR 283.5
Anti-rabbit IFN-gamma mAb (MT318), PF488P
3110-71-100T
Mabtech AB
100 tests
EUR 304.5
Anti-rabbit IFN-gamma mAb (MT318), PF647P
3110-72-100T
Mabtech AB
100 tests
EUR 304.5
ELISA Flex: Bovine IL-2 (ALP)
3111-1A-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Bovine IL-2 (ALP)
3111-1A-6
Mabtech AB
for 6 plates
EUR 351.75
ELISA Flex: Bovine IL-2 (HRP)
3111-1H-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Bovine IL-2 (HRP)
3111-1H-6
Mabtech AB
for 6 plates
EUR 351.75
ELISpot Flex: Bovine IL-2 (ALP)
3111-2A
Mabtech AB
for 4 plates
EUR 609
ELISpot Flex: Bovine IL-2 (HRP)
3111-2H
Mabtech AB
for 4 plates
EUR 609
Anti-bovine IL-2 mAb (MT11A31), unconjugated
3111-3-1000
Mabtech AB
1 mg
EUR 840
Anti-bovine IL-2 mAb (MT11A31), unconjugated
3111-3-250
Mabtech AB
250 µg
EUR 241.5
ELISpot Plus: Bovine IL-2 (ALP)
3111-4APW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Bovine IL-2 (ALP)
3111-4APW-2
Mabtech AB
2 plates
EUR 535.5
ELISpot Plus: Bovine IL-2 (HRP)
3111-4HPW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Bovine IL-2 (HRP)
3111-4HPW-2
Mabtech AB
2 plates
EUR 535.5
Anti-bovine IL-2 mAb (MT3B3), unconjugated
3111-5-250
Mabtech AB
250 µg
EUR 241.5
Anti-bovine IL-2 mAb (MT3B3), biotin
3111-6-250
Mabtech AB
250 µg
EUR 283.5
Anti-bovine IL-2 mAb (MT3B3), PF488P
3111-71-100T
Mabtech AB
100 tests
EUR 304.5
Anti-bovine IL-2 mAb (MT3B3), PF647P
3111-72-100T
Mabtech AB
100 tests
EUR 304.5
ELISA Flex: Ferret IFN-gamma (ALP)
3112-1A-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Ferret IFN-gamma (ALP)
3112-1A-6
Mabtech AB
for 6 plates
EUR 351.75
ELISA Flex: Ferret IFN-gamma (HRP)
3112-1H-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Ferret IFN-gamma (HRP)
3112-1H-6
Mabtech AB
for 6 plates
EUR 351.75
ELISpot Flex: Ferret IFN-gamma (ALP)
3112-2A
Mabtech AB
for 4 plates
EUR 609
ELISpot Flex: Ferret IFN-gamma (HRP)
3112-2H
Mabtech AB
for 4 plates
EUR 609
Anti-ferret IFN-gamma mAb (MTF14), unconjugated
3112-3-1000
Mabtech AB
1 mg
EUR 840
Anti-ferret IFN-gamma mAb (MTF14), unconjugated
3112-3-250
Mabtech AB
250 µg
EUR 241.5
ELISpot Plus: Ferret IFN-gamma (ALP)
3112-4APW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Ferret IFN-gamma (ALP)
3112-4APW-2
Mabtech AB
2 plates
EUR 535.5
ELISpot Plus: Ferret IFN-gamma (HRP)
3112-4HPW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Ferret IFN-gamma (HRP)
3112-4HPW-2
Mabtech AB
2 plates
EUR 535.5
Anti-ferret IFN-gamma mAb (MTF19), biotin
3112-6-1000
Mabtech AB
1 mg
EUR 1044.75
Anti-ferret IFN-gamma mAb (MTF19), biotin
3112-6-250
Mabtech AB
250 µg
EUR 283.5
Anti-ferret IFN-gamma mAb (MTF14), PF488P
3112-71-100T
Mabtech AB
100 tests
EUR 304.5
Anti-ferret IFN-gamma mAb (MTF14), PF647P
3112-72-100T
Mabtech AB
100 tests
EUR 304.5
ELISA Flex: Canine IFN-gamma (ALP)
3113-1A-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Canine IFN-gamma (ALP)
3113-1A-6
Mabtech AB
for 6 plates
EUR 351.75
ELISA Flex: Canine IFN-gamma (HRP)
3113-1H-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Canine IFN-gamma (HRP)
3113-1H-6
Mabtech AB
for 6 plates
EUR 351.75
ELISpot Flex: Canine IFN-gamma (ALP)
3113-2A
Mabtech AB
for 4 plates
EUR 609
ELISpot Flex: Canine IFN-gamma (HRP)
3113-2H
Mabtech AB
for 4 plates
EUR 609
Anti-canine IFN-gamma mAb (MT13), unconjugated
3113-3-1000
Mabtech AB
1 mg
EUR 840
Anti-canine IFN-gamma mAb (MT13), unconjugated
3113-3-250
Mabtech AB
250 µg
EUR 241.5
ELISpot Plus: Canine IFN-gamma (ALP)
3113-4APW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Canine IFN-gamma (ALP)
3113-4APW-2
Mabtech AB
2 plates
EUR 535.5
ELISpot Plus: Canine IFN-gamma (HRP)
3113-4HPW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Canine IFN-gamma (HRP)
3113-4HPW-2
Mabtech AB
2 plates
EUR 535.5
Anti-canine IFN-gamma mAb (MT166), biotin
3113-6-1000
Mabtech AB
1 mg
EUR 1044.75
Anti-canine IFN-gamma mAb (MT166), biotin
3113-6-250
Mabtech AB
250 µg
EUR 283.5
Anti-bovine IL-8 (CXCL8) mAbs (MT8H6/8F19), unconjugated
3114-1-1000
Mabtech AB
1 mg
EUR 840
Anti-bovine IL-8 (CXCL8) mAbs (MT8H6/8F19), unconjugated
3114-1-250
Mabtech AB
250 µg
EUR 241.5
ELISA Flex: Bovine IL-8 (ALP)
3114-1A-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Bovine IL-8 (ALP)
3114-1A-6
Mabtech AB
for 6 plates
EUR 351.75
ELISA Flex: Bovine IL-8 (HRP)
3114-1H-20
Mabtech AB
for 20 plates
EUR 651
ELISA Flex: Bovine IL-8 (HRP)
3114-1H-6
Mabtech AB
for 6 plates
EUR 351.75
ELISpot Flex: Bovine IL-8 (ALP)
3114-2A
Mabtech AB
for 4 plates
EUR 609
ELISpot Flex: Bovine IL-8 (HRP)
3114-2H
Mabtech AB
for 4 plates
EUR 609
Anti-bovine IL-8 (CXCL8) mAb (MT8H6), unconjugated
3114-3-1000
Mabtech AB
1 mg
EUR 840
Anti-bovine IL-8 (CXCL8) mAb (MT8H6), unconjugated
3114-3-250
Mabtech AB
250 µg
EUR 241.5
ELISpot Plus: Bovine IL-8 (ALP)
3114-4APW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Bovine IL-8 (ALP)
3114-4APW-2
Mabtech AB
2 plates
EUR 535.5
ELISpot Plus: Bovine IL-8 (HRP)
3114-4HPW-10
Mabtech AB
10 plates
EUR 2420.25
ELISpot Plus: Bovine IL-8 (HRP)
3114-4HPW-2
Mabtech AB
2 plates
EUR 535.5
The BDNF / TrkB pathway, when over expressed in tumors, correlate with reduced clinical prognosis and short life span of the patient. Targeting the BDNF / TrkB pathway and the use of Trk inhibitors, such as entrectinib, larotrectinib., A promising method for tumor targeted therapy. This review provides an overview of the role of TrkB pathway in the pathogenesis of cancer and its value as a potential therapeutic target.
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