MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress

MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress

Metabolic inflammation is associated with increased expression of a saturated free fatty acid, proinflammatory cytokines, chemokines, and adipose oxidative stress. Macrophage inflammatory protein (MIP) -1α recruit inflammatory cells such as monocytes, macrophages, and neutrophils in adipose tissue; However, the mechanism of promoting the expression of MIP-1α remains unclear.

We hypothesized that the co-induced by palmitate and tumor necrosis factor (TNF) -α in monocytic cells / macrophages can be further enhanced by the presence of reactive oxygen species (ROS) -mediated oxidative stress MIP-1α. To investigate this, THP-1 cells monocytic and human macrophages primary co-stimulated by palmitate and TNF-α and mRNA and protein levels of MIP-1α was measured by using transcription quantitative reverse, polymerase chain reaction (qRT-PCR) and commercial tests enzyme -linked immunosorbent assay (ELISA), respectively.

Cognate receptors of palmitic, pulses like receptor (TLR) -4, was blunted by genetic ablation, neutralization, and chemical inhibition. The involvement of TLR4-downstream pathway, interferon regulatory factor (IRF) -3 or myeloid differentiation (MYD) -88 factors, determined by using IRF3-siRNA or MyD88-deficient cells. induced oxidative stress in cells by hydrogen peroxide (H2O2) and ROS induction treatment was measured with dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay. Data show that MIP-1α gene expression / protein upregulated in cells co-stimulated by palmitate / TNF-α compared with those stimulated with either palmitic or TNF-α (P <0.05).

Furthermore, TLR4-IRF3 the pathway involved in cooperative induction of MIP-1α in THP-1 cells, and this kooperatititas between palmitate and TNF-α is a clathrin-dependent and is also required signal through the c-Jun and nuclear factor kappa-light- to medium-chain enhancer activated B cells (NF-kB). In particular, the ROS itself induced MIP-1α and could further promote the secretion of MIP-1α together with palmitate and TNF-α. In conclusion, palmitic and TNF-α co-induced MIP-1α in human monocytic cells via TLR4-IRF3 and signaling pathways involving c-Jun / NF-kB. Importantly, oxidative stress leads to ROS-driven amplification MIP-1α, which may have significance for inflammatory metabolism.

MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress
MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress

Progress in Regulating Cancer tumorigenicity and metastasis through TrkB signaling

Clinical Pathology various human malignancies supported by tropomyosin receptor kinase (Trk) B specific receptor TrkB which is derived neurotrophic factor from binding brain (BDNF) and TrkB .TrkB fusion protein has been observed for over-expressed in many cancer patients. In addition, they observed in several cell types. A multiple signaling pathways may be affected by abnormal activation pathway of BDNF / TrkB. These signaling pathways in-clude PI3K / Akt, transactivation of EGFR, phospholipase C-gamma (PLCγ) pathway, Ras-Raf-MEK-ERK pathway, Jak / STAT pathway, and nuclear factor kappa-light-chain-enhancer of B cells activated (NF-kB) pathway.

EGFR (Ab-869) Antibody

CSB-PA877124-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against EGFR (Ab-869). Recognizes EGFR (Ab-869) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:200

EGFR (Ab-869) Antibody

8B7065 50ug
EUR 368
Description: EGFR (Ab-869) Antibody

anti-EGFR (Ab-869)

LF-PA20123 100 ul
EUR 400.8
Description: Rabbit polyclonal to EGFR

Anti-EGFR (Ab-869) Antibody

Y021222 100 µg
EUR 285

Rabbit anti EGFR (Ab-869)

AP21222 100ul
EUR 307.2

NFκB-p100/p52 (Ab-869) Antibody

E021016-1 50μg/50μl
EUR 100
Description: Available in various conjugation types.

NFκB-p100/p52 (Ab-869) Antibody

E021016-2 100μg/100μl
EUR 170
Description: Available in various conjugation types.

anti-NFκB-p100/p52 (Ab-869)

LF-PA20318 100 ul
EUR 400.8
Description: Rabbit polyclonal to NFκB-p100/p52

OAEC00563-50UG - EGFR (Ab-869) Antibody

OAEC00563-50UG 50ug
EUR 259

NF-kB p100/p52 (Ab-869)

ANTY021016 100ug
EUR 259

Apolipoprotein E2, (ApoE2) (1mg) Human Recombinant

AE-100-10 1 mg
EUR 330

Apolipoprotein E3, (ApoE3) (1mg) Human Recombinant

AE-101-10 1 mg
EUR 330

Apolipoprotein E4, (ApoE4) (1mg) Human Recombinant

AE-102-10 1 mg
EUR 330

Apolipoprotein E4, (ApoE4) (1mg) 1-199 Human Recombinant

AE-103-10 1 mg
EUR 330

Apolipoprotein E4, (ApoE4) (1mg) 1-162 Human Recombinant

AE-104-10 1 mg
EUR 330

Apolipoprotein E4, (ApoE4) (1mg) 1-132 Human Recombinant

AE-105-10 1 mg
EUR 330

Alpha-Synuclein (1.0 mg) Human, Recombinant

AS-600-10 1 mg
EUR 170.5

Alpha-Synuclein (10x 1mg) Human, Recombinant

AS-600-100 10 X 1.0mg
EUR 1358.5

Alpha-Synuclein (50x 1mg) Human, Recombinant

As-600-500 50 X 1.0mg
EUR 5967.5

Alpha-Synuclein 1-120 (1.0 mg) Human, Recombinant

AS-602-10 1 mg
EUR 170.5

Alpha-Synuclein (A30P) (1.0 mg) Human, Recombinant

AS-603-10 1 mg
EUR 247.5

Alpha-Synuclein (A53T) (1.0 mg) Human, Recombinant

AS-604-10 1 mg
EUR 247.5

Alpha-Synuclein (E46K) (1.0 mg) Human, Recombinant

AS-605-10 1 mg
EUR 247.5

Alpha-Synuclein (1.0 mg) Mouse, Recombinant

AS-650-10 1 mg
EUR 170.5

Mouse IgG Anti-Transthyretin (39-44) (Amyloid Specific) 100 ug

AT-550-01 100 ug
EUR 357.5

Mouse IgG Anti-Transthyretin (56-61) (Amyloid Specific) 100 ug

AT-560-01 100 ug
EUR 357.5

Transthyretin (Wild Type) (10 X 1.0mg) Human, Recombinant

T-500-10 1 mg
EUR 1628

Transthyretin (L12P) (1.0 mg) Human, Recombinant

T-501-10 1 mg
EUR 330

Transthyretin (V30G) (1.0 mg) Human, Recombinant

T-502-10 1 mg
EUR 247.5

Transthyretin (A36P) (1.0 mg) Human, Recombinant

T-503-10 1 mg
EUR 330

Transthyretin (D18G) (1.0 mg) Human, Recombinant

T-504-10 1 mg
EUR 330

Transthyretin (V30M) (1.0 mg) Human, Recombinant

T-505-10 1 mg
EUR 247.5

Transthyretin (G53E) (1.0 mg) Human, Recombinant

T-506-10 1 mg
EUR 247.5

Transthyretin (V122I) (1.0 mg) Human, Recombinant

T-507-10 1 mg
EUR 247.5

Transthyretin (F87M/L110M) (1.0mg), Human, Recombinant

T-509-10 1 mg
EUR 247.5

Transthyretin (L55P) (1.0 mg) Human, Recombinant

T-510-10 1 mg
EUR 247.5

Transthyretin (F64S) (1.0mg), Human, Recombinant

T-511-10 1 mg
EUR 247.5

Transthyretin (Y69H) (1.0 mg) Human, Recombinant

T-512-10 1 mg
EUR 247.5

Transthyretin (T119M) (1.0 mg) Human, Recombinant

T-515-10 1 mg
EUR 247.5

Transthyretin (T60A) (1.0mg) Human, Recombinant

T-516-10 1 mg
EUR 330

Transthyretin (A97S) (1.0mg) Human, Recombinant

T-517-10 1 mg
EUR 330

Transthyretin (S52P) (1.0 mg) Human, Recombinant

T-518-10 1 mg
EUR 247.5

Transthyretin (L111M) (1.0 mg) Human, Recombinant

T-519-10 1 mg
EUR 247.5

Transthyretin (V30I) (1.0 mg) Human, Recombinant

T-535-10 1 mg
EUR 247.5

ELISA Flex: Bovine TNF-alpha (ALP)

3012-1A-20 for 20 plates
EUR 651

ELISA Flex: Bovine TNF-alpha (ALP)

3012-1A-6 for 6 plates
EUR 351.75

ELISA Flex: Bovine TNF-alpha (HRP)

3012-1H-20 for 20 plates
EUR 651

ELISA Flex: Bovine TNF-alpha (HRP)

3012-1H-6 for 6 plates
EUR 351.75

ELISpot Flex: Bovine TNF-alpha (ALP)

3012-2A for 4 plates
EUR 609

ELISpot Flex: Bovine TNF-alpha (HRP)

3012-2H for 4 plates
EUR 609

Anti-bovine TNF-alpha mAb (MTF4918), unconjugated

3012-3-1000 1 mg
EUR 840

Anti-bovine TNF-alpha mAb (MTF4918), unconjugated

3012-3-250 250 µg
EUR 241.5

ELISpot Plus: Bovine TNF-alpha (ALP)

3012-4APW-10 10 plates
EUR 2420.25

ELISpot Plus: Bovine TNF-alpha (ALP)

3012-4APW-2 2 plates
EUR 535.5

ELISpot Plus Bovine TNF-alpha (HRP)

3012-4HPW-10 10 plates
EUR 2420.25

ELISpot Plus Bovine TNF-alpha (HRP)

3012-4HPW-2 2 plates
EUR 535.5

Anti-bovine TNF-alpha mAb (MT771), biotin

3012-6-1000 1 mg
EUR 1044.75

Anti-bovine TNF-alpha mAb (MT771), biotin

3012-6-250 250 µg
EUR 283.5

ELISA Flex: Porcine IL-17A (ALP)

3020-1A-20 for 20 plates
EUR 651

ELISA Flex: Porcine IL-17A (ALP)

3020-1A-6 for 6 plates
EUR 351.75

ELISA Flex: Porcine IL-17A (HRP)

3020-1H-20 for 20 plates
EUR 651

ELISA Flex: Porcine IL-17A (HRP)

3020-1H-6 for 6 plates
EUR 351.75

ELISpot Flex: Porcine IL-17A (ALP)

3020-2A for 4 plates
EUR 609

ELISpot Flex: Porcine IL-17A (HRP)

3020-2H for 4 plates
EUR 609

ELISpot Plus: Porcine IL-17A (ALP)

3020-4APW-10 10 plates
EUR 2420.25

ELISpot Plus: Porcine IL-17A (ALP)

3020-4APW-2 2 plates
EUR 535.5

ELISpot Plus: Porcine IL-17A (HRP)

3020-4HPW-10 10 plates
EUR 2420.25

ELISpot Plus: Porcine IL-17A (HRP)

3020-4HPW-2 2 plates
EUR 535.5

Anti-porcine IL-17A mAb (MTP853), biotin

3020-6-1000 1 mg
EUR 1044.75

Anti-porcine IL-17A mAb (MTP853), biotin

3020-6-250 250 µg
EUR 283.5

ELISpot Flex: Woodchuck IFN-gamma (ALP)

3101-2A for 4 plates
EUR 609

ELISpot Flex: Woodchuck IFN-gamma (HRP)

3101-2H for 4 plates
EUR 609

Anti-woodchuck IFN-gamma mAb (MT247), unconjugated

3101-3-1000 1 mg
EUR 840

Anti-woodchuck IFN-gamma mAb (MT247), unconjugated

3101-3-250 250 µg
EUR 241.5

Anti-woodchuck IFN-gamma mAb (MT225), biotin

3101-6-1000 1 mg
EUR 1044.75

Anti-woodchuck IFN-gamma mAb (MT225), biotin

3101-6-250 250 µg
EUR 283.5

ELISA Flex: Hamster IFN-gamma (ALP)

3102-1A-20 for 20 plates
EUR 651

ELISA Flex: Hamster IFN-gamma (ALP)

3102-1A-6 for 6 plates
EUR 351.75

ELISA Flex: Hamster IFN-gamma (HRP)

3102-1H-20 for 20 plates
EUR 651

ELISA Flex: Hamster IFN-gamma (HRP)

3102-1H-6 for 6 plates
EUR 351.75

ELISpot Flex: Hamster IFN-gamma (ALP)

3102-2A for 4 plates
EUR 609

ELISpot Flex: Hamster IFN-gamma (HRP)

3102-2H for 4 plates
EUR 609

Anti-hamster IFN-gamma mAb (MTH21), unconjugated

3102-3-1000 1 mg
EUR 840

Anti-hamster IFN-gamma mAb (MTH21), unconjugated

3102-3-250 250 µg
EUR 241.5

ELISpot Plus: Hamster IFN-gamma (ALP)

3102-4APW-10 10 plates
EUR 2420.25

ELISpot Plus: Hamster IFN-gamma (ALP)

3102-4APW-2 2 plates
EUR 535.5

ELISpot Plus: Hamster IFN-gamma (HRP)

3102-4HPW-10 10 plates
EUR 2420.25

ELISpot Plus: Hamster IFN-gamma (HRP)

3102-4HPW-2 2 plates
EUR 535.5

Anti-hamster IFN-gamma mAb (MTH29), biotin

3102-6-1000 1 mg
EUR 1044.75

Anti-hamster IFN-gamma mAb (MTH29), biotin

3102-6-250 250 µg
EUR 283.5

Anti-ferret IL-2 mAb (MT264), unconjugated

3104-1-1000 1 mg
EUR 840

Anti-ferret IL-2 mAb (MT264), unconjugated

3104-1-250 250 µg
EUR 241.5

ELISA Flex: Ferret IL-2 (ALP)

3104-1A-20 for 20 plates
EUR 651

ELISA Flex: Ferret IL-2 (ALP)

3104-1A-6 for 6 plates
EUR 351.75

ELISA Flex: Ferret IL-2 (HRP)

3104-1H-20 for 20 plates
EUR 651

ELISA Flex: Ferret IL-2 (HRP)

3104-1H-6 for 6 plates
EUR 351.75

ELISpot Flex: Ferret IL-2 (ALP)

3104-2A for 4 plates
EUR 609

ELISpot Flex: Ferret IL-2 (HRP)

3104-2H for 4 plates
EUR 609

Anti-ferret IL-2 mAbs (MT264/271), unconjugated

3104-3-1000 1 mg
EUR 840

Anti-ferret IL-2 mAbs (MT264/271), unconjugated

3104-3-250 250 µg
EUR 241.5

ELISA Flex: Bovine IL-17A (ALP)

3109-1A-20 for 20 plates
EUR 651

ELISA Flex: Bovine IL-17A (ALP)

3109-1A-6 for 6 plates
EUR 351.75

ELISA Flex: Bovine IL-17A (HRP)

3109-1H-20 for 20 plates
EUR 651

ELISA Flex: Bovine IL-17A (HRP)

3109-1H-6 for 6 plates
EUR 351.75

ELISpot Flex: Bovine IL-17A (ALP)

3109-2A for 4 plates
EUR 609

ELISpot Flex: Bovine IL-17A (HRP)

3109-2H for 4 plates
EUR 609

Anti-bovine IL-17A mAb (MT49A7), unconjugated

3109-3-1000 1 mg
EUR 840

Anti-bovine IL-17A mAb (MT49A7), unconjugated

3109-3-250 250 µg
EUR 241.5

ELISpot Plus: Bovine IL-17A (ALP)

3109-4APW-10 10 plates
EUR 2420.25

ELISpot Plus: Bovine IL-17A (ALP)

3109-4APW-2 2 plates
EUR 535.5

ELISpot Plus: Bovine IL-17A (HRP)

3109-4HPW-10 10 plates
EUR 2420.25

ELISpot Plus: Bovine IL-17A (HRP)

3109-4HPW-2 2 plates
EUR 535.5

Anti-bovine IL-17A mAb (MT51B8), biotin

3109-6-1000 1 mg
EUR 1044.75

Anti-bovine IL-17A mAb (MT51B8), biotin

3109-6-250 250 µg
EUR 283.5

ELISA Flex: Rabbit IFN-gamma (ALP)

3110-1A-20 for 20 plates
EUR 651

ELISA Flex: Rabbit IFN-gamma (ALP)

3110-1A-6 for 6 plates
EUR 351.75

ELISA Flex: Rabbit IFN-gamma (HRP)

3110-1H-20 for 20 plates
EUR 651

ELISA Flex: Rabbit IFN-gamma (HRP)

3110-1H-6 for 6 plates
EUR 351.75

ELISpot Flex: Rabbit IFN-gamma (ALP)

3110-2A for 4 plates
EUR 609

ELISpot Flex: Rabbit IFN-gamma (HRP)

3110-2H for 4 plates
EUR 609

Anti-rabbit IFN-gamma mAb (MT327), unconjugated

3110-3-1000 1 mg
EUR 840

Anti-rabbit IFN-gamma mAb (MT327), unconjugated

3110-3-250 250 µg
EUR 241.5

ELISpot Plus: Rabbit IFN-gamma (ALP)

3110-4APW-10 10 plates
EUR 2420.25

ELISpot Plus: Rabbit IFN-gamma (ALP)

3110-4APW-2 2 plates
EUR 535.5

ELISpot Plus: Rabbit IFN-gamma (HRP)

3110-4HPW-10 10 plates
EUR 2420.25

ELISpot Plus: Rabbit IFN-gamma (HRP)

3110-4HPW-2 2 plates
EUR 535.5

Anti-rabbit IFN-gamma mAb (MT318), biotin

3110-6-1000 1 mg
EUR 1044.75

Anti-rabbit IFN-gamma mAb (MT318), biotin

3110-6-250 250 µg
EUR 283.5

Anti-rabbit IFN-gamma mAb (MT318), PF488P

3110-71-100T 100 tests
EUR 304.5

Anti-rabbit IFN-gamma mAb (MT318), PF647P

3110-72-100T 100 tests
EUR 304.5

ELISA Flex: Bovine IL-2 (ALP)

3111-1A-20 for 20 plates
EUR 651

ELISA Flex: Bovine IL-2 (ALP)

3111-1A-6 for 6 plates
EUR 351.75

ELISA Flex: Bovine IL-2 (HRP)

3111-1H-20 for 20 plates
EUR 651

ELISA Flex: Bovine IL-2 (HRP)

3111-1H-6 for 6 plates
EUR 351.75

ELISpot Flex: Bovine IL-2 (ALP)

3111-2A for 4 plates
EUR 609

ELISpot Flex: Bovine IL-2 (HRP)

3111-2H for 4 plates
EUR 609

Anti-bovine IL-2 mAb (MT11A31), unconjugated

3111-3-1000 1 mg
EUR 840

Anti-bovine IL-2 mAb (MT11A31), unconjugated

3111-3-250 250 µg
EUR 241.5

ELISpot Plus: Bovine IL-2 (ALP)

3111-4APW-10 10 plates
EUR 2420.25

ELISpot Plus: Bovine IL-2 (ALP)

3111-4APW-2 2 plates
EUR 535.5

ELISpot Plus: Bovine IL-2 (HRP)

3111-4HPW-10 10 plates
EUR 2420.25

ELISpot Plus: Bovine IL-2 (HRP)

3111-4HPW-2 2 plates
EUR 535.5

Anti-bovine IL-2 mAb (MT3B3), unconjugated

3111-5-250 250 µg
EUR 241.5

Anti-bovine IL-2 mAb (MT3B3), biotin

3111-6-250 250 µg
EUR 283.5

Anti-bovine IL-2 mAb (MT3B3), PF488P

3111-71-100T 100 tests
EUR 304.5

Anti-bovine IL-2 mAb (MT3B3), PF647P

3111-72-100T 100 tests
EUR 304.5

ELISA Flex: Ferret IFN-gamma (ALP)

3112-1A-20 for 20 plates
EUR 651

ELISA Flex: Ferret IFN-gamma (ALP)

3112-1A-6 for 6 plates
EUR 351.75

ELISA Flex: Ferret IFN-gamma (HRP)

3112-1H-20 for 20 plates
EUR 651

ELISA Flex: Ferret IFN-gamma (HRP)

3112-1H-6 for 6 plates
EUR 351.75

ELISpot Flex: Ferret IFN-gamma (ALP)

3112-2A for 4 plates
EUR 609

ELISpot Flex: Ferret IFN-gamma (HRP)

3112-2H for 4 plates
EUR 609

Anti-ferret IFN-gamma mAb (MTF14), unconjugated

3112-3-1000 1 mg
EUR 840

Anti-ferret IFN-gamma mAb (MTF14), unconjugated

3112-3-250 250 µg
EUR 241.5

ELISpot Plus: Ferret IFN-gamma (ALP)

3112-4APW-10 10 plates
EUR 2420.25

ELISpot Plus: Ferret IFN-gamma (ALP)

3112-4APW-2 2 plates
EUR 535.5

ELISpot Plus: Ferret IFN-gamma (HRP)

3112-4HPW-10 10 plates
EUR 2420.25

ELISpot Plus: Ferret IFN-gamma (HRP)

3112-4HPW-2 2 plates
EUR 535.5

Anti-ferret IFN-gamma mAb (MTF19), biotin

3112-6-1000 1 mg
EUR 1044.75

Anti-ferret IFN-gamma mAb (MTF19), biotin

3112-6-250 250 µg
EUR 283.5

Anti-ferret IFN-gamma mAb (MTF14), PF488P

3112-71-100T 100 tests
EUR 304.5

Anti-ferret IFN-gamma mAb (MTF14), PF647P

3112-72-100T 100 tests
EUR 304.5

ELISA Flex: Canine IFN-gamma (ALP)

3113-1A-20 for 20 plates
EUR 651

ELISA Flex: Canine IFN-gamma (ALP)

3113-1A-6 for 6 plates
EUR 351.75

ELISA Flex: Canine IFN-gamma (HRP)

3113-1H-20 for 20 plates
EUR 651

ELISA Flex: Canine IFN-gamma (HRP)

3113-1H-6 for 6 plates
EUR 351.75

ELISpot Flex: Canine IFN-gamma (ALP)

3113-2A for 4 plates
EUR 609

ELISpot Flex: Canine IFN-gamma (HRP)

3113-2H for 4 plates
EUR 609

Anti-canine IFN-gamma mAb (MT13), unconjugated

3113-3-1000 1 mg
EUR 840

Anti-canine IFN-gamma mAb (MT13), unconjugated

3113-3-250 250 µg
EUR 241.5

ELISpot Plus: Canine IFN-gamma (ALP)

3113-4APW-10 10 plates
EUR 2420.25

ELISpot Plus: Canine IFN-gamma (ALP)

3113-4APW-2 2 plates
EUR 535.5

ELISpot Plus: Canine IFN-gamma (HRP)

3113-4HPW-10 10 plates
EUR 2420.25

ELISpot Plus: Canine IFN-gamma (HRP)

3113-4HPW-2 2 plates
EUR 535.5

Anti-canine IFN-gamma mAb (MT166), biotin

3113-6-1000 1 mg
EUR 1044.75

Anti-canine IFN-gamma mAb (MT166), biotin

3113-6-250 250 µg
EUR 283.5

Anti-bovine IL-8 (CXCL8) mAbs (MT8H6/8F19), unconjugated

3114-1-1000 1 mg
EUR 840

Anti-bovine IL-8 (CXCL8) mAbs (MT8H6/8F19), unconjugated

3114-1-250 250 µg
EUR 241.5

ELISA Flex: Bovine IL-8 (ALP)

3114-1A-20 for 20 plates
EUR 651

ELISA Flex: Bovine IL-8 (ALP)

3114-1A-6 for 6 plates
EUR 351.75

ELISA Flex: Bovine IL-8 (HRP)

3114-1H-20 for 20 plates
EUR 651

ELISA Flex: Bovine IL-8 (HRP)

3114-1H-6 for 6 plates
EUR 351.75

ELISpot Flex: Bovine IL-8 (ALP)

3114-2A for 4 plates
EUR 609

ELISpot Flex: Bovine IL-8 (HRP)

3114-2H for 4 plates
EUR 609

Anti-bovine IL-8 (CXCL8) mAb (MT8H6), unconjugated

3114-3-1000 1 mg
EUR 840

Anti-bovine IL-8 (CXCL8) mAb (MT8H6), unconjugated

3114-3-250 250 µg
EUR 241.5

ELISpot Plus: Bovine IL-8 (ALP)

3114-4APW-10 10 plates
EUR 2420.25

ELISpot Plus: Bovine IL-8 (ALP)

3114-4APW-2 2 plates
EUR 535.5

ELISpot Plus: Bovine IL-8 (HRP)

3114-4HPW-10 10 plates
EUR 2420.25

ELISpot Plus: Bovine IL-8 (HRP)

3114-4HPW-2 2 plates
EUR 535.5

The BDNF / TrkB pathway, when over expressed in tumors, correlate with reduced clinical prognosis and short life span of the patient. Targeting the BDNF / TrkB pathway and the use of Trk inhibitors, such as entrectinib, larotrectinib., A promising method for tumor targeted therapy. This review provides an overview of the role of TrkB pathway in the pathogenesis of cancer and its value as a potential therapeutic target.

Tony

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