MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress

MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress

Metabolic inflammation is associated with increased expression of a saturated free fatty acid, proinflammatory cytokines, chemokines, and adipose oxidative stress. Macrophage inflammatory protein (MIP) -1α recruit inflammatory cells such as monocytes, macrophages, and neutrophils in adipose tissue; However, the mechanism of promoting the expression of MIP-1α remains unclear.

We hypothesized that the co-induced by palmitate and tumor necrosis factor (TNF) -α in monocytic cells / macrophages can be further enhanced by the presence of reactive oxygen species (ROS) -mediated oxidative stress MIP-1α. To investigate this, THP-1 cells monocytic and human macrophages primary co-stimulated by palmitate and TNF-α and mRNA and protein levels of MIP-1α was measured by using transcription quantitative reverse, polymerase chain reaction (qRT-PCR) and commercial tests enzyme -linked immunosorbent assay (ELISA), respectively.

Cognate receptors of palmitic, pulses like receptor (TLR) -4, was blunted by genetic ablation, neutralization, and chemical inhibition. The involvement of TLR4-downstream pathway, interferon regulatory factor (IRF) -3 or myeloid differentiation (MYD) -88 factors, determined by using IRF3-siRNA or MyD88-deficient cells. induced oxidative stress in cells by hydrogen peroxide (H2O2) and ROS induction treatment was measured with dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay. Data show that MIP-1α gene expression / protein upregulated in cells co-stimulated by palmitate / TNF-α compared with those stimulated with either palmitic or TNF-α (P <0.05).

Furthermore, TLR4-IRF3 the pathway involved in cooperative induction of MIP-1α in THP-1 cells, and this kooperatititas between palmitate and TNF-α is a clathrin-dependent and is also required signal through the c-Jun and nuclear factor kappa-light- to medium-chain enhancer activated B cells (NF-kB). In particular, the ROS itself induced MIP-1α and could further promote the secretion of MIP-1α together with palmitate and TNF-α. In conclusion, palmitic and TNF-α co-induced MIP-1α in human monocytic cells via TLR4-IRF3 and signaling pathways involving c-Jun / NF-kB. Importantly, oxidative stress leads to ROS-driven amplification MIP-1α, which may have significance for inflammatory metabolism.

MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress
MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress

Progress in Regulating Cancer tumorigenicity and metastasis through TrkB signaling

Clinical Pathology various human malignancies supported by tropomyosin receptor kinase (Trk) B specific receptor TrkB which is derived neurotrophic factor from binding brain (BDNF) and TrkB .TrkB fusion protein has been observed for over-expressed in many cancer patients. In addition, they observed in several cell types. A multiple signaling pathways may be affected by abnormal activation pathway of BDNF / TrkB. These signaling pathways in-clude PI3K / Akt, transactivation of EGFR, phospholipase C-gamma (PLCγ) pathway, Ras-Raf-MEK-ERK pathway, Jak / STAT pathway, and nuclear factor kappa-light-chain-enhancer of B cells activated (NF-kB) pathway.

Rabbit anti-Human IgM (µ chain), F(ab)'2 Fragment

AS16-3370 1 mg
EUR 250

Donkey anti-Mouse IgG (H&L), F(ab)'2 Fragment

AS16-3437 1,0 mg
EUR 224

Donkey anti-Rabbit IgG (H&L), F(ab)'2 Fragment

AS16-3521 1,0 mg
EUR 206

Goat anti-Human IgG Fc, F(ab)'2 fragment, FITC conjugated

AS10-1236 0,5 mg
EUR 233

Goat anti-Human IgG Fc, Biotin conjugated, F(ab)'2 fragment

AS10-806 0,5 mg
EUR 206

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, Unconjugated

AS10-846 1 mg
EUR 206

Goat anti-Human IgG Fc, F(ab)'2 Fragment, DyLight® 488 conjugated, min, cross-reactivity to human IgA, IgM or IgG F(ab)'2 fragment

AS16-3353 0,5 mg
EUR 196

Donkey anti-Mouse IgG (H&L), F(ab)'2 Fragment, FITC conjugated

AS16-3450 0,5 mg
EUR 206

Donkey anti-Mouse IgG (H&L), F(ab)'2 Fragment, HRP conjugated

AS16-3454 0,5 mg
EUR 233

Donkey anti-Mouse IgG (H&L), F(ab)'2 Fragment, TRITC conjugated

AS16-3467 0,5 mg
EUR 206

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, HRP conjugated

AS10-1009 0,5 mg
EUR 246

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, FITC conjugated

AS10-1011 0,5 mg
EUR 185

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, TRITC conjugated

AS10-1018 0,5 mg
EUR 185

Goat anti-Human IgG + IgA + IgM, F(ab)'2 fragment, HRP conjugated

AS10-1039 0,5 mg
EUR 246

Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, HRP conjugated

AS10-1045 0,5 mg
EUR 246

Goat anti-Human IgA (alpha chain), F(ab)'2 fragment, FITC conjugated

AS10-1076 0,5 mg
EUR 239

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin conjugated

AS10-1081 0,5 mg
EUR 233

Goat anti-Human IgA (alpha chain), F(ab)'2 fragment, TRITC conjugated

AS10-1097 0,5 mg
EUR 233

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, ALP conjugated

AS10-1139 0,5 mg
EUR 233

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, Biotin conjugated

AS10-1200 0,5 mg
EUR 246

Goat anti-Human IgA + IgG + IgM, F(ab)'2 fragment, ALP conjugated

AS10-1222 0,5 mg
EUR 233

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, ALP conjugated

AS10-1237 0,5 mg
EUR 246

Goat anti-Human IgA + IgG + IgM, F(ab)'2 fragment, Biotin conjugated

AS10-1253 0,5 mg
EUR 233

Goat anti-Human IgA + IgG + IgM, F(ab)'2 fragment, FITC conjugated

AS10-1275 0,5 mg
EUR 233

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugated

AS10-1289 0,5 mg
EUR 175

Goat anti-Human IgG (H&L), F(ab)'2 fragment, FITC conjugated

AS10-1295 0,5 mg
EUR 185

Goat anti-Human IgA + IgG + IgM, F(ab)'2 fragment, TRITC conjugated

AS10-1306 0,5 mg
EUR 233

Goat anti-Human IgA heavy (alpha chain), F(ab)'2 fragment, Unconjugated

AS10-743 1 mg
EUR 206

Goat anti-Human IgG (H&L), F(ab)'2 fragment, ALP conjugated

AS10-774 0,5 mg
EUR 206

Goat anti-Human IgG (H&L), F(ab)'2 fragment, Biotin conjugated

AS10-775 0,5 mg
EUR 206

Goat anti-Human IgG (H&L), F(ab)'2 fragment, HRP conjugated

AS10-779 0,5 mg
EUR 206

Goat anti-Human IgG Fc, F(ab)'2 fragment, Affinity purified, Unconjugated

AS10-805 1 mg
EUR 233

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, ALP conjugated

AS10-848 0,5 mg
EUR 233

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, Biotin conjugated

AS10-849 0,5 mg
EUR 206

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, HRP conjugated

AS10-852 0,5 mg
EUR 206

Goat anti-Human IgG (H&L), F(ab)'2 fragment, TRITC conjugated

AS10-946 0,5 mg
EUR 185

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, FITC conjugated

AS10-967 0,5 mg
EUR 175

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, FITC conjugated

AS10-991 0,5 mg
EUR 246

Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, Biotin conjugated

AS10-997 0,5 mg
EUR 246

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated

AS10-998 0,5 mg
EUR 185

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, Affinity purified, Unconjugated

AS10-1029 1 mg
EUR 246

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated

AS10-1163 1 mg
EUR 175

Goat anti-Human IgA + IgG + IgM, F(ab)'2 fragment, Affinity purified, Unconjugated

AS10-1184 1 mg
EUR 175

TSH (beta) | thyroid stimulating hormone (Affinity purified, F(ab)2' fragment, goat antibody)

AS10-1325 0,5 mg
EUR 532

Goat anti-Human IgA heavy (alpha chain), F(ab)'2 fragment, Biotin conjugated

AS10-745 0,5 mg
EUR 233

Goat anti-Human IgA heavy (alpha chain), F(ab)'2 fragment, HRP conjugated

AS10-746 0,5 mg
EUR 206

Goat anti-Human IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated

AS10-773 1 mg
EUR 206

Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated

AS10-960 1 mg
EUR 233

EGFR (Ab-869) Antibody

21222 100ul
EUR 319

EGFR (Ab-869) Antibody

21222-100ul 100ul
EUR 302.4

EGFR (Ab-869) Antibody

21222-50ul 50ul
EUR 224.4

EGFR (Ab-869) Antibody

8B7065 50ug
EUR 368
Description: EGFR (Ab-869) Antibody

EGFR (Ab-869) Antibody

MBS7131969-01mL 0.1mL
EUR 270

EGFR (Ab-869) Antibody

MBS7131969-5x01mL 5x0.1mL
EUR 1200

EGFR (Ab-869) Antibody

E11-7065B 100μg/100μl
EUR 225
Description: Available in various conjugation types.

EGFR (Ab-869) Antibody

E021222-1 50μg/50μl
EUR 100
Description: Available in various conjugation types.

EGFR (Ab-869) Antibody

E021222-2 100μg/100μl
EUR 170
Description: Available in various conjugation types.

anti-EGFR (Ab-869)

LF-PA20123 100 ul
EUR 400.8
Description: Rabbit polyclonal to EGFR

EGFR (Ab-869) Antibody

CSB-PA877124- each
EUR 402
Description: A polyclonal antibody against EGFR (Ab-869). Recognizes EGFR (Ab-869) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:200

EGFR (Ab-869) Antibody

CSB-PA877124-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against EGFR (Ab-869). Recognizes EGFR (Ab-869) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:200

EGFR (Ab-869) Antibody

MBS856842-005mg 0.05mg
EUR 190

EGFR (Ab-869) Antibody

MBS856842-01mg 0.1mg
EUR 255

EGFR (Ab-869) Antibody

MBS856842-01mLAF405M 0.1mL(AF405M)
EUR 465

EGFR (Ab-869) Antibody

MBS856842-01mLAF546 0.1mL(AF546)
EUR 465

EGFR (Ab-869) Antibody

MBS856842-01mLAF750 0.1mL(AF750)
EUR 465

EGFR (Ab-869) Antibody

MBS858436-01mg 0.1mg
EUR 305

EGFR (Ab-869) Antibody

MBS858436-01mLAF405L 0.1mL(AF405L)
EUR 465

EGFR (Ab-869) Antibody

MBS858436-01mLAF405S 0.1mL(AF405S)
EUR 465

EGFR (Ab-869) Antibody

MBS858436-01mLAF610 0.1mL(AF610)
EUR 465

EGFR (Ab-869) Antibody

MBS858436-01mLAF635 0.1mL(AF635)
EUR 465

EGFR (Ab-869) Antibody

MBS9409871-005mL 0.05mL
EUR 245

EGFR (Ab-869) Antibody

MBS9409871-01mL 0.1mL
EUR 305

EGFR (Ab-869) Antibody

MBS9409871-5x01mL 5x0.1mL
EUR 1230

Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 633 conjugated

AS12-2182 0,5 mg
EUR 206

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 633 conjugated

AS12-2189 0,5 mg
EUR 206

Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, DyLight® 800 conjugated

AS12-2381 0,5 mg
EUR 233

Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 800 conjugated

AS12-2428 0,5 mg
EUR 246

Donkey anti-Rabbit IgG (H&L), F(ab)'2 Fragment, DyLight® 488 conjugated

AS16-3526 0,5 mg
EUR 233

Goat anti-Rabbit IgG (H&L), F(ab)'2 Fragment, DyLight® 488 conjugated

AS16-3527 0,5 mg
EUR 202

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 488 conjugated

AS10-1220 0,5 mg
EUR 206

Goat anti-Rat IgG (H&L), F(ab)'2 fragment, HRP conjugated, min,reactivity to human, mouse IgG

AS10-1145 0,5 mg
EUR 246

Goat anti-Human IgG Fc, F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity bovine/mouse/rabbit serum

AS10-814 0,5 mg
EUR 246

Goat anti-Human IgG Fc, F(ab)'2 fragment, HRP conjugated, min, cross-reactivity bovine/mouse/rabbit serum

AS10-817 0,5 mg
EUR 233

Goat anti-Human IgM (µ chain), F(ab)'2 Fragment, min, cross-reactivity to IgG from human or mouse

AS16-3371 1,0 mg
EUR 238

Goat anti-Human IgG Fc, F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine,mouse,rabbit serum

AS10-1001 0,5 mg
EUR 246

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to human IgG/serum

AS10-1002 0,5 mg
EUR 233

Goat anti-Rat IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to human, mouse IgG

AS10-1023 0,5 mg
EUR 246

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to human IgG/serum

As10-1071 0,5 mg
EUR 233

Goat anti-Rat IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to human, mouse IgG

AS10-1088 0,5 mg
EUR 246

Goat anti-Human IgG Fc, F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovine,mouse,rabbit serum

AS10-1099 0,5 mg
EUR 246

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to human IgG/serum

AS10-1189 0,5 mg
EUR 233

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, ALP conjugated, min, cross-reactivity to human IgG/serum

AS10-1193 0,5 mg
EUR 246

Goat anti-Rat IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to human, mouse IgG

AS10-1234 0,5 mg
EUR 246

Goat anti-Human IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity bovine/mouse/rabbit serum

AS10-782 0,5 mg
EUR 233

Goat anti-Human IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity bovine/mouse/rabbit serum

AS10-785 0,5 mg
EUR 233

Goat anti-Human IgG Fc, F(ab)'2 fragment, ALP conjugated, min, cross-reactivity to bovine/mouse/rabbit serum

AS10-813 0,5 mg
EUR 246

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to human IgG/serum

AS10-981 0,5 mg
EUR 233

Goat anti-Human IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovine,mouse,rabbit serum

AS10-1015 0,5 mg
EUR 233

Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to human, mouse,Rat IgG

AS10-1058 0,5 mg
EUR 246

Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to human, mouse,Rat IgG

AS10-1065 0,5 mg
EUR 246

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to human IgG or IgA

AS10-1090 0,5 mg
EUR 233

Goat anti-Human IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine,mouse,rabbit serum

AS10-1157 0,5 mg
EUR 233

Goat anti-Rat IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to human, mouse IgG

AS10-1215 1 mg
EUR 233

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to human IgG or IgA

AS10-1287 0,5 mg
EUR 259

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to human IgA+IgG

AS10-1296 1 mg
EUR 233

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, ALP conjugated, min, cross-reactivity to human IgG or IgA

AS10-1298 0,5 mg
EUR 273

Goat anti-Human IgG (H&L), F(ab)'2 fragment, ALP conjugated, min, cross-reactivity to bovine/mouse/rabbit serum

AS10-781 0,5 mg
EUR 206

Goat anti-Human IgG Fc, F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to bovine/mouse/rabbit serum

AS10-812 1 mg
EUR 233

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to human IgG or IgA

AS10-959 0,5 mg
EUR 246

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to human IgG/serum

AS10-961 1 mg
EUR 233

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to human IgG or IgA

AS10-979 0,5 mg
EUR 273

Goat anti-Human IgG Fc, F(ab)'2 Fragment, min, cross-reactivity to Human IgA/IgM, Bovine, Horse, Mouse, Rabbit Serum

AS16-3350 0,5 mg
EUR 216

Goat anti-Mouse IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG

AS16-3459 1,0 mg
EUR 284

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovin, human, mouse IgG/serum

AS10-1042 0,5 mg
EUR 233

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine,human, mouse IgG/serum

AS10-1059 0,5 mg
EUR 233

Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to human, mouse,Rat IgG

AS10-1077 1 mg
EUR 246

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to bovine,human, mouse IgG/serum

AS10-1146 0,5 mg
EUR 233

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to bovine,human, mouse IgG/serum

AS10-1153 0,5 mg
EUR 233

Goat anti-Rat IgG (H&L), F(ab)'2 fragment, DyLight® 488 conjugated, min, cross-reactivity to human, mouse lgG

AS10-1217 0,5 mg
EUR 259

Goat anti-Human IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to bovine/mouse/rabbit serum

AS10-780 1 mg
EUR 233

Goat anti-Rat IgG (H&L), F(ab)'2 fragment, DyLight® 550 conjugated, min, cross-reactivity to human, mouse lgG

AS12-1980 0,5 mg
EUR 246

Goat anti-Human IgG Fc, F(ab)'2 Fragment, min, cross-reactivity to bovine, horse, mouse or rabbit serum proteins, mouse IgG1

AS16-3356 1,0 mg
EUR 238

Goat anti-Mouse IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein

AS16-3461 1,0 mg
EUR 252

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to bovine, human, mouse IgG/serum

AS10-982 1 mg
EUR 190

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 800 conjugated, min, cross-reactivity to human IgG or serum proteins

AS12-2436 0,5 mg
EUR 220

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, ALP conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG

AS16-3441 0,5 mg
EUR 264

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG

AS16-3445 0,5 mg
EUR 300

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG

AS16-3452 0,5 mg
EUR 284

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG

AS16-3456 0,5 mg
EUR 300

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG

AS16-3468 0,5 mg
EUR 284

Goat anti-Rabbit IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to non-immunoglobulin rabbit serum proteins and human serum proteins

AS16-3530 1,0 mg
EUR 203

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, ALP (alkaline phosphatase) conjugated, min, cross-reactivity to bovine,human, mouse IgG/serum

AS10-1017 0,5 mg
EUR 233

Goat anti-Human IgG Fc, F(ab)'2 Fragment, FITC conjugated, min, cross-reactivity to bovine, horse, mouse or rabbit serum proteins, mouse IgG1

AS16-3354 0,5 mg
EUR 238

Goat anti-Human IgG Fc, F(ab)'2 Fragment, HRP conjugated, min, cross-reactivity to bovine, horse, mouse or rabbit serum proteins, mouse IgG1

AS16-3355 0,5 mg
EUR 245

Goat anti-Human IgG Fc, F(ab)'2 Fragment, TRITC conjugated, min, cross-reactivity to bovine, horse, mouse or rabbit serum proteins, mouse IgG1

AS16-3358 0,5 mg
EUR 275

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, ALP conjugated min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein

AS16-3440 0,5 mg
EUR 257

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin-conjugated, min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein

AS16-3462 0,5 mg
EUR 238

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein

AS16-3463 0,5 mg
EUR 214

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein

AS16-3464 0,5 mg
EUR 183

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein

AS16-3465 0,5 mg
EUR 214

Rabbit anti EGFR (Ab-869)

AP21222 100ul
EUR 307.2

Anti-EGFR (Ab-869) Antibody

Y021222 100 µg
EUR 285

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, DyLight® 594 conjugated, min, cross-reactivity to bovine, human, or Mouse lgG or serum proteins

AS12-2083 0,5 mg
EUR 206

Goat anti-Rabbit IgG (H&L) -F(ab)'2 fragment, DyLight® 650 conjugated, min, cross-reactivity to bovine, human, or Mouse lgG or serum proteins

AS12-2337 0,5 mg
EUR 220

Goat anti-Mouse IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)

AS16-3460 1,0 mg
EUR 406

Donkey anti-Rabbit IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to Bovine, Chicken, Goat, Guinea Pig, Hamster, Horse, Human, Mouse, Rat or Sheep

AS16-3522 0,5 mg
EUR 213

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 550 conjugated,min, cross-reactivity to bovine, horse, human, pig or rabbit serum proteins

AS12-1945 0,5 mg
EUR 206

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, DyLight® 550 conjugated,min, cross-reactivity to bovine, human, or Mouse lgG or serum proteins

AS12-1968 0,5 mg
EUR 206

Donkey anti-Mouse IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG

AS16-3458 0,5 mg
EUR 213

Goat anti-Mouse IgG (H&L), F(ab)'2 Fragment, ALP conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)

AS16-3442 0,5 mg
EUR 381

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)

AS16-3446 0,5 mg
EUR 442

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)

AS16-3457 0,5 mg
EUR 442

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)

AS16-3469 0,5 mg
EUR 406

Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, ALP conjugate, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG

AS16-3439 0,5 mg
EUR 360

Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG

AS16-3444 0,5 mg
EUR 300

Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG

AS16-3451 0,5 mg
EUR 287

Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG

AS16-3455 0,5 mg
EUR 300

Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugate, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG

AS16-3466 0,5 mg
EUR 287

Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 633 conjugated, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG

AS12-2183 0,5 mg
EUR 334

NFκB-p100/p52 (Ab-869) Antibody

E021016-1 50μg/50μl
EUR 100
Description: Available in various conjugation types.

NFκB-p100/p52 (Ab-869) Antibody

E021016-2 100μg/100μl
EUR 170
Description: Available in various conjugation types.

anti-NFκB-p100/p52 (Ab-869)

LF-PA20318 100 ul
EUR 400.8
Description: Rabbit polyclonal to NFκB-p100/p52

NF-kB p100/p52 (Ab-869)

ANTY021016 100ug
EUR 259

NFkappaB-p100/p52 (Ab-869) Antibody

MBS856780-005mg 0.05mg
EUR 190

NFkappaB-p100/p52 (Ab-869) Antibody

MBS856780-01mg 0.1mg
EUR 255

NFkappaB-p100/p52 (Ab-869) Antibody

MBS856780-01mLAF405M 0.1mL(AF405M)
EUR 465

NFkappaB-p100/p52 (Ab-869) Antibody

MBS856780-01mLAF546 0.1mL(AF546)
EUR 465

NFkappaB-p100/p52 (Ab-869) Antibody

MBS856780-01mLAF750 0.1mL(AF750)
EUR 465

OAEC00563-50UG - EGFR (Ab-869) Antibody

OAEC00563-50UG 50ug
EUR 259

NF-κB p100/p52 (Ab-869) Antibody

8B7165 50ug
EUR 368
Description: NF-κB p100/p52 (Ab-869) Antibody

NF-κB p100/p52 (Ab-869) Antibody

E11-7165B 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Polyclonal NF-KB p100 Antibody (Ab-869)

APR05373G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NF-KB p100 (Ab-869). This antibody is tested and proven to work in the following applications:

NF-kappaB p100/p52 (Ab-869) Antibody

MBS8510216-01mg 0.1mg
EUR 305

NF-kappaB p100/p52 (Ab-869) Antibody

MBS8510216-01mLAF405L 0.1mL(AF405L)
EUR 465

NF-kappaB p100/p52 (Ab-869) Antibody

MBS8510216-01mLAF405S 0.1mL(AF405S)
EUR 465

NF-kappaB p100/p52 (Ab-869) Antibody

MBS8510216-01mLAF610 0.1mL(AF610)
EUR 465

NF-kappaB p100/p52 (Ab-869) Antibody

MBS8510216-01mLAF635 0.1mL(AF635)
EUR 465

NF-KB p100/p52 Antibody (Ab-869)

MBS9212334-01mL 0.1mL
EUR 425

NF-KB p100/p52 Antibody (Ab-869)

MBS9212334-5x01mL 5x0.1mL
EUR 1887

Anti-Cardiac Troponin I Antibody

24001 100ug
EUR 235

Anti-Cardiac Troponin I Antibody

24002 100ug
EUR 235

Anti-DR3 (ED) Antibody

2401 100ug
EUR 445

Anti-DR3 (NT) Antibody

2402 100ug
EUR 445

Anti-DR3 (CT) Antibody

2403 100ug
EUR 445

Anti-DR4 (CT) Antibody

2404 100ug
EUR 445

Anti-RAIDD (CT) Antibody

2406 100ug
EUR 445

Anti-FLIPγ/δ (CT) Antibody

2407 100ug
EUR 445

Anti-Caspase-10 (CT) Antibody

2408 100ug
EUR 445

Anti-DFF (CT) Antibody

2409 100ug
EUR 445

Anti-DFF (NT) Antibody

2410 100ug
EUR 445

The BDNF / TrkB pathway, when over expressed in tumors, correlate with reduced clinical prognosis and short life span of the patient. Targeting the BDNF / TrkB pathway and the use of Trk inhibitors, such as entrectinib, larotrectinib., A promising method for tumor targeted therapy. This review provides an overview of the role of TrkB pathway in the pathogenesis of cancer and its value as a potential therapeutic target.

Tony

Related Posts

Inflammatory Diseases and Vitamin E – What Do We Know and Where Do We Go?

Inflammatory Diseases and Vitamin E – What Do We Know and Where Do We Go?

Protective Effect of Epigallocatechin-3-Gallate (EGCG) in Diseases with Uncontrolled Immune Activation: Could Such a Scenario Be Helpful to Counteract COVID-19?

Protective Effect of Epigallocatechin-3-Gallate (EGCG) in Diseases with Uncontrolled Immune Activation: Could Such a Scenario Be Helpful to Counteract COVID-19?

Toll-Like Receptor 4 (TLR4)/Opioid Receptor Pathway Crosstalk and Impact on Opioid Analgesia, Immune Function, and Gastrointestinal Motility

Toll-Like Receptor 4 (TLR4)/Opioid Receptor Pathway Crosstalk and Impact on Opioid Analgesia, Immune Function, and Gastrointestinal Motility

Glyoxal and Methylglyoxal as E-cigarette Vapor Ingredients-Induced Pro-Inflammatory Cytokine and Mucins Expression in Human Nasal Epithelial Cells

Glyoxal and Methylglyoxal as E-cigarette Vapor Ingredients-Induced Pro-Inflammatory Cytokine and Mucins Expression in Human Nasal Epithelial Cells

No Comment

Leave a Reply

Your email address will not be published.

February 2025
M T W T F S S
 12
3456789
10111213141516
17181920212223
2425262728  

Recent Posts

Categories

Tags

Pages